University of Nottingham Malaysia
Faculty of Science and Engineering
     
  
 

Image of Yan Pan

Yan Pan

Associate Professor,

Contact

  • workRoom B1B26a Block B
    Malaysia Campus
    Jalan Broga
    43500 Semenyih
    Selangor Darul Ehsan
    Malaysia
  • work+6 (03) 8725 3444

Biography

1999-2004, Bachelor of Lab Science and technology, Shanghai Second Medical University, Shanghai China

2005-2009, Doctor of Philosophy in Pharmacology, International Medical University, Kuala Lumpur, Malaysia

2006, Certificate in Good Clinical Practice, International Medical University, Kuala Lumpur, Malaysia

2016, Fellow of The Higher Education Academy

Teaching Summary

Module convener: Pharmacological Basis of Therapeutics; Toxicology and Pharmacogenetics

Co-teaching: Human Physiology; Asthma, Allergy and Immune disease; Core skills in BMS; Structure Function and Analysis of Protein; Renal and Endocrine Diseases; BMS final year project

Tutoring & Supervising: Final Year Projects, postgraduate research studies

Research Summary

Cytochrome P450 (CYP) enzymes are a superfamily of mono-oxygenases responsible for metabolising a wide spectrum of xenobiotics including drugs as well as endogenous compounds such as fatty acids.… read more

Recent Publications

Current Research

Cytochrome P450 (CYP) enzymes are a superfamily of mono-oxygenases responsible for metabolising a wide spectrum of xenobiotics including drugs as well as endogenous compounds such as fatty acids. Accumulation of drugs or toxins in human body may result in serious adverse toxic effects. The hydrophilicity of the metabolite is usually increased after being oxidised by CYP, which facilitates the elimination of foreign compounds from human body. However, the activities of CYPs can be inhibited or induced by various types of chemicals. As a result, drugs or food have potential to decrease or increase the elimination of co-administrated drugs, leading to adverse drug reactions or treatment failures.

My current research interest is to investigate the modulatory effects of commonly used traditional herbs on the activities of several most important human CYP isoforms (CYP2C9, CYP2C19, CYP2D6 and CYP3A4) by in vitro evaluation. Moreover, CYPs exhibit polymorphisms. Lower or no activities of CYPs are expressed in the population carrying polymorphic genes. These people are not able to metabolise a certain group of drugs, and they are more prone to adverse drug reactions. Thus, I am also interested in investigating the activities of CYP variants and the mechanisms involved.

Moreover, my on-going project is also investigating effects of ZnO nanoparticles on CYP activities as well as their toxicological effects using cells and C. elegans.

Future Research

In addition to in vitro investigation, I am keen to correlate in vitro with in vivo findings by performing clinical studies.

Faculty of Science and Engineering

University of Nottingham Malaysia
Jalan Broga, 43500 Semenyih
Selangor Darul Ehsan
Malaysia

telephone: +6 (03) 8924 8000
fax: +6 (03) 8924 8001

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