Yan Pan

Contact

• workRoom B1B26a Block B
  Malaysia Campus
  Jalan Broga
  43500 Semenyih
  Selangor Darul Ehsan
  Malaysia
• work+6 (03) 8725 3444
• Pan.Yan@nottingham.edu.my

Biography

1999-2004, Bachelor of Lab Science and technology, Shanghai Second Medical University, Shanghai China

2005-2009, Doctor of Philosophy in Pharmacology, International Medical University, Kuala Lumpur, Malaysia

2006, Certificate in Good Clinical Practice, International Medical University, Kuala Lumpur, Malaysia

2016, Fellow of The Higher Education Academy

Teaching Summary

Module convener: Pharmacological Basis of Therapeutics; Toxicology and Pharmacogenetics

Co-teaching: Human Physiology; Asthma, Allergy and Immune disease; Core skills in BMS; Structure Function and Analysis of Protein; Renal and Endocrine Diseases; BMS final year project

Tutoring & Supervising: Final Year Projects, postgraduate research studies

Research Summary

Cytochrome P450 (CYP) enzymes are a superfamily of mono-oxygenases responsible for metabolising a wide spectrum of xenobiotics including drugs as well as endogenous compounds such as fatty acids.… read more

Recent Publications

• DONG, AMELIA NATHANIA, AHEMAD, NAFEES, PAN, YAN, PALANISAMY, UMA DEVI, YIAP, BEOW CHIN and ONG, CHIN ENG, 2022. Role of P34S, G169R, R296C, and S486T Substitutions in Ligand Access and Catalysis for Cytochrome P450 2D6 Allelic Variants CYP2D6*14A and CYP2D6*14B. Drug metabolism letters.
• ABU-BAKAR, A'EDAH, TAN, BOON HOOI, HALIM, HASSERI, RAMLI, SALFARINA, PAN, YAN and ONG, CHIN ENG, 2022. Cytochromes P450: Role in Carcinogenesis and Relevance to Cancers. Current drug metabolism.
• SHAROEN YU MING LIM, JASON SIAU EE LOO, MUSTAFA ALSHAGGA, MOHAMMED ABDULLAH ALSHAWSH, CHIN ENG ONG and YAN PAN, 2022. In vitro and In Silico Studies of Interactions of Cathinone with Human Recombinant Cytochrome P450 CYP(1A2), CYP2A6, CYP2B6, CYP2C8, CYP2C19, CYP2E1, CYP2J2, and CYP3A5 Toxicology Reports. 9, 759-768
• CHONG CL, FANG CM, PUNG SY, ONG CE, PUNG YF, KONG C and PAN Y, 2021. Current Updates On the In vivo Assessment of Zinc Oxide Nanoparticles Toxicity Using Animal Models Bionanosci. (IF: 0.277)

• View all publications

Current Research

Cytochrome P450 (CYP) enzymes are a superfamily of mono-oxygenases responsible for metabolising a wide spectrum of xenobiotics including drugs as well as endogenous compounds such as fatty acids. Accumulation of drugs or toxins in human body may result in serious adverse toxic effects. The hydrophilicity of the metabolite is usually increased after being oxidised by CYP, which facilitates the elimination of foreign compounds from human body. However, the activities of CYPs can be inhibited or induced by various types of chemicals. As a result, drugs or food have potential to decrease or increase the elimination of co-administrated drugs, leading to adverse drug reactions or treatment failures.

My current research interest is to investigate the modulatory effects of commonly used traditional herbs on the activities of several most important human CYP isoforms (CYP2C9, CYP2C19, CYP2D6 and CYP3A4) by in vitro evaluation. Moreover, CYPs exhibit polymorphisms. Lower or no activities of CYPs are expressed in the population carrying polymorphic genes. These people are not able to metabolise a certain group of drugs, and they are more prone to adverse drug reactions. Thus, I am also interested in investigating the activities of CYP variants and the mechanisms involved.

Moreover, my on-going project is also investigating effects of ZnO nanoparticles on CYP activities as well as their toxicological effects using cells and C. elegans.

Future Research

In addition to in vitro investigation, I am keen to correlate in vitro with in vivo findings by performing clinical studies.

• DONG, AMELIA NATHANIA, AHEMAD, NAFEES, PAN, YAN, PALANISAMY, UMA DEVI, YIAP, BEOW CHIN and ONG, CHIN ENG, 2022. Role of P34S, G169R, R296C, and S486T Substitutions in Ligand Access and Catalysis for Cytochrome P450 2D6 Allelic Variants CYP2D6*14A and CYP2D6*14B. Drug metabolism letters.
• ABU-BAKAR, A'EDAH, TAN, BOON HOOI, HALIM, HASSERI, RAMLI, SALFARINA, PAN, YAN and ONG, CHIN ENG, 2022. Cytochromes P450: Role in Carcinogenesis and Relevance to Cancers. Current drug metabolism.
• SHAROEN YU MING LIM, JASON SIAU EE LOO, MUSTAFA ALSHAGGA, MOHAMMED ABDULLAH ALSHAWSH, CHIN ENG ONG and YAN PAN, 2022. In vitro and In Silico Studies of Interactions of Cathinone with Human Recombinant Cytochrome P450 CYP(1A2), CYP2A6, CYP2B6, CYP2C8, CYP2C19, CYP2E1, CYP2J2, and CYP3A5 Toxicology Reports. 9, 759-768
• CHONG CL, FANG CM, PUNG SY, ONG CE, PUNG YF, KONG C and PAN Y, 2021. Current Updates On the In vivo Assessment of Zinc Oxide Nanoparticles Toxicity Using Animal Models Bionanosci. (IF: 0.277)
• CHIENG JIN YU, YASOTHA SUGUMARAN and PAN YAN, 2021. Awareness and Knowledge of Nurses towards Hepatitis B Virus Infection at A Tertiary Hospital in Selangor, Malaysia Borneo Journal of Medical Sciences. 15(1), 11-20
• LIM, SHAROEN YU MING, CHIENG, JIN YU and PAN, YAN, 2021. Recent insights on anti-dengue virus (DENV) medicinal plants: review on in vitro, in vivo and in silico discoveries ALL LIFE. 14(1), 1-33
• PAN YAN, TYE KEAN HONG and MUSTAFA ALSHAGGA, 2021. Prevalence of herbal products use and perceptions on drug-herb interactions among university students in Klang Valley Malaysia – a cross sectional study Bangladesh Journal of Medical Science. 20(2), 11-16
• TAN, BOON HOOI, AHEMAD, NAFEES, PAN, YAN, PALANISAMY, UMA DEVI, OTHMAN, IEKHSAN and ONG, CHIN ENG, 2021. In vitro inhibitory effects of glucosamine, chondroitin and diacerein on human hepatic CYP2D6. Drug metabolism and personalized therapy.
• DONG, AMELIA NATHANIA, TAN, BOON HOOI, PAN, YAN and ONG, CHIN ENG, 2021. The CYP2R1 Enzyme: Structure, Function, Enzymatic Properties and Genetic Polymorphism JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES. 24, 94-112
• TAN, BOON HOOI, AHEMAD, NAFEES, PAN, YAN, PALANISAMY, UMA DEVI, OTHMAN, IEKHSAN and ONG, CHIN ENG, 2021. In vitro inhibitory effects of glucosamine, chondroitin and diacerein on human hepatic CYP2D6 Drug Metabolism and Personalized Therapy. 36(4), 259-270
• LIM, SHAROEN YU MING, ALSHAGGA, MUSTAFA AHMED, ALSHAWSH, MOHAMMED ABDULLAH, ONG, CHIN ENG and PAN, YAN, 2021. In vitro effects of 95% khat ethanol extract (KEE) on human recombinant cytochrome P450 (CYP)1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C19, CYP2E1, CYP2J2 and CYP3A5 Drug Metabolism and Personalized Therapy. 37(1),
• AMNA SHAH, ONG CHIN ENG and PAN YAN, 2021. Unveiling the role of cytochrome P450 (CYP2E1) in human brain specifically in parkinson’s disease-literature review Current Drug Metabolism. 22(9), 698-708
• CHONG, ZHI XIONG, HO, WAN YONG, YAN, PAN and ALSHAGGA, MUSTAFA AHMED, 2020. Evaluation of Khat (Catha edulis) Use as a Risk Factor of Cancer: A Systematic Review. Asian Pacific journal of cancer prevention : APJCP. 21(4), 881-895
• CHIENG, JIN YU, ARAVAN, LOGARUBAN, ARIMUTHU, DURGA A., TAN, WENDY AI YING, NAIDU, THARANI and PAN, YAN, 2020. Factors Associated With Intensive Care Attention of Dengue Patients A Retrospective Cohort Study From a Single Center INFECTIOUS DISEASES IN CLINICAL PRACTICE. 28(1), 27-33
• DONG, AMELIA NATHANIA, AHEMAD, NAFEES, PAN, YAN, PALANISAMY, UMA DEVI, YIAP, BEOW CHIN and ONG, CHIN ENG, 2020. The Molecular and Enzyme Kinetic Basis for Altered Activity of Three Cytochrome P450 2C19 Variants Found in the Chinese Population CURRENT MOLECULAR PHARMACOLOGY. 13(3), 233-244
• LIM, S. Y. M., ALSHAGGA, M., ONG, C. E., CHIENG, J. Y. and PAN, Y., 2020. Cytochrome P450 4B1 (CYP4B1) as a target in cancer treatment HUMAN & EXPERIMENTAL TOXICOLOGY. 39(6), 785-796
• CHIENG JIN YU, CHIANG YOONG FEI and PAN YAN, 2020. Acute epiploic appendagitis as a rare case of acute abdomen: a Case report Gastroenterology and Hepatology Letters. 2(2),
• CHIENG JIN YU, YASOTHA SUGUMARAN, MUSTAFA ALSHAGGA and PAN YAN, 2020. Demographic and Clinical Characteristics of Inflammatory Bowel Disease (IBD) in the Patients Attending A Public Hospital In Central Malaysia – A Descriptive Study From A Single Centre Vietnam Journal of Public Health. 6(2),
• CHAI, BOON KHENG, AL-SHAGGA, MUSTAFA, PAN, YAN, THEN, SUE-MIAN, TING, KANG NEE, LOH, HWEI-SAN and MOHANKUMAR, SURESH K, 2019. Cis-9, Trans-11 Conjugated Linoleic Acid Reduces Phosphoenolpyruvate Carboxykinase Expression and Hepatic Glucose Production in HepG2 Cells. Lipids. 54(6-7), 369-379
• PAN, YAN, ONG, CHIN ENG, PUNG, YUH FEN and CHIENG, JIN YU, 2019. The current understanding of the interactions between nanoparticles and cytochrome P450 enzymes - a literature-based review XENOBIOTICA. 49(7), 863-876
• LIM, SHAROEN YU MING, AZIDIN, ATHIRA RAFHANA BINTI, UNG, YEE TZE, AL-SHAGGA, MUSTAFA, ALSHAWSH, MOHAMMED ABDULLAH, MOHAMED, ZAHURIN, ONG, CHIN ENG and PAN, YAN, 2019. Effect of 95% Ethanol Khat Extract and Cathinone on in vitro Human Recombinant Cytochrome P450 (CYP) 2C9, CYP2D6, and CYP3A4 Activity EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS. 44(3), 423-431
• TAN BH, AHEMAD N, PAN Y, PALANISAMY UD, OTHMAN I, YIAP BC and ONG CE, 2019. Expression of cytochrome P450 2C9 (CYP2C9) in Escherichia coli and its functional characterization Asia Pacific Journal of Molecular Biology and Biotechnology. 27(1), 43-55
• DONG, AMELIA NATHANIA, AHEMAD, NAFEES, PAN, YAN, PALANISAMY, UMA DEVI, YIAP, BEOW CHIN and ONG, CHIN ENG, 2019. Functional and structural characterisation of common cytochrome P450 2D6 allelic variants-roles of Pro34 and Thr107 in catalysis and inhibition NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 392(8), 1015-1029
• CHAI, BOON KHENG, AL-SHAGGA, MUSTAFA, PAN, YAN, THEN, SUE-MIAN, TING, KANG NEE, LOH, HWEI-SAN and MOHANKUMAR, SURESH K., 2019. Cis-9, Trans-11 Conjugated Linoleic Acid Reduces Phosphoenolpyruvate Carboxykinase Expression and Hepatic Glucose Production in HepG2 Cells LIPIDS. 54(6-7), 369-379
• THEN RU FAH, TAN YI JUN, PAN YAN and CHIENG JIN YU, 2019. Appropriateness Of Proton Pump Inhibitors Prescription In Patients Admitted To A Malaysian Tertiary Hospital International Journal of Public Health Research. 9(1),
• CHIN ENG ONG, AMELIA DONG, BOON HOOI TAN and PAN YAN, 2019. Cytochromes P450, Cardiovascular Homeostasis and Diseases. In: PETER GRUNWALD, ed., Pharmaceutical Biocatalysis: fundamentals, enzyme inhibitors, and enzymes in health and diseases Singapore: Jenny Stanford Publishing Pte.Ltd.. 567-587
• TAN, BOON HOOI, AHEMAD, NAFEES, PAN, YAN, PALANISAMY, UMA DEVI, OTHMAN, IEKHSAN, YIAP, BEOW CHIN and ONG, CHIN ENG, 2018. Cytochrome P450 2C9-natural antiarthritic interactions: evaluation of inhibition magnitude and prediction from in vitro data. Biopharmaceutics & drug disposition.
• TAN, BOON HOOI, AHEMAD, NAFEES, PAN, YAN, PALANISAMY, UMA DEVI, OTHMAN, IEKHSAN, YIAP, BEOW CHIN and ONG, CHIN ENG, 2018. Cytochrome P450 2C9-natural antiarthritic interactions: Evaluation of inhibition magnitude and prediction from in vitro data BIOPHARMACEUTICS & DRUG DISPOSITION. 39(4), 205-217
• DONG, AMELIA NATHANIA, PAN, VAN, PALANISAMY, UMA DEVI, YIAP, BEOW CHIN, AHEMAD, NAFEES and ONG, CHIN ENG, 2018. Site-Directed Mutagenesis of Cytochrome P450 2D6 and 2C19 Enzymes: Expression and Spectral Characterization of Naturally Occurring Allelic Variants APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY. 186(1), 132-144
• YAN, PAN, ENG, ONG CHIN and YU, CHIENG JIN, 2018. A Review on the Expression and Metabolic Features of Orphan Human Cytochrome P450 2S1 (CYP2S1) CURRENT DRUG METABOLISM. 19(11), 917-929
• DONG, AMELIA NATHANIA, TAN, BOON HOOI, PAN, YAN and ONG, CHIN ENG, 2018. Cytochrome P450 genotype-guided drug therapies: An update on current states CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY. 45(10), 991-1001
• UNG, YEE TZE, ONG, CHIN ENG and PAN, YAN, 2018. Current High-Throughput Approaches of Screening Modulatory Effects of Xenobiotics on Cytochrome P450 (CYP) Enzymes. High-throughput. 7(4),
• OZTURK, MESUT, ASLAN, SERDAR, SAGLAM, DILEK, BEKCI, TUMAY and BILGICI, MELTEM CEYHAN, 2018. Epiploic Appendagitis as a Rare Cause of Acute Abdomen in the Pediatric Population: Report of Three Cases EURASIAN JOURNAL OF MEDICINE. 50(1), 56-58
• TAN, BOON HOOI, PAN, YAN, DONG, AMELIA NATHANIA and ONG, CHIN ENG, 2017. In vitro and in silico Approaches to Study Cytochrome P450-Mediated Interactions JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES. 20, 319-328
• PAN, YAN and ONG, ENG CHIN, 2017. Cytochrome P450 2W1 (CYP2W1) - ready for use as the biomarker and drug target for cancer? XENOBIOTICA. 47(10), 923-932
• LAU, PUI SHEN, LEONG, KENNY VOON GAH, ONG, CHIN ENG, DONG, AMELIA NATHANIA HUI MIN and PAN, YAN, 2017. In Vitro Functional Characterisation of Cytochrome P450 (CYP) 2C19 Allelic Variants CYP2C19*23 and CYP2C19*24 BIOCHEMICAL GENETICS. 55(1), 48-62
• ONG CHIN ENG, PAN YAN and MAK JOON WAH, 2017. The roles of cytochrome P450 in vascular biology and cardiovascular homeostasis International Journal of Clinical and Experimental Medicine. 10(1), 1624-1636
• MUN CHIENG TAN, OOI CHUAN NG, RAY YEE PAUL YAP, YAN PAN and JIN YU CHIENG, 2017. Colorectal cancer screening using immunochemical fecal occult blood test Malaysian Journal of Public Health Medicine. 17(1), 33-37
• CHIENG JIN YU, AHMAD AMIRUL HAFIZ BIN HARIS, ANG SHIH YUAN and PAN YAN, 2017. Assessment of the level of knowledge of colorectal cancer among public at outpatient clinics in Serdang Hospital: a survey based study The Medical Journal of Malaysia. 72(6), 333-339
• PAN YAN, CHIA JIE HSU, RHUN YIAN KOH, CHIN ENG ONG and JIN YU CHIENG, 2016. In vitro study of modulatory effects of extracts of Strobilanthes Crispus on human cDNA-expressed cytochrome P450 2A6 (CYP2A6) and CYP3A4 The All Results Journals: Biol. 7(1), 1-12
• PAN YAN and CHIENG JIN YU, 2016. CELIAC DISEASE IN EAST AND SOUTHEAST ASIAN COUNTRIES: CURRENT STATUS AND CHALLENGES. Vietnam Journal of Medicine and Pharmacy. 11(2), 76-86
• CHIENG JY, PAN Y and LOONG YY, 2015. Prevalence Of Helicobacter Pyloric Infection Among Patients Attending Gastroenterology Endoscopy Unit At Serdang Hospital Malaysian Journal of Medicine and Health Sciences (MJMHS). 11(1), 11-17
• LAU PS, LEONG KVG, ONG CE and PAN Y, 2015. Functional characterization of cytochrome P450 2C19 allelic variants CYP2C19*23 and CYP2C19*24 In: Golden Helix Symposia 2015.
• DONG AN, ONG CE, PAN Y, PALANISAMY UD and ISMAIL R, 2015. Palanisamy UD, Ismail R. Functional Characterization of Cytochrome P450 2D6 (CYP2D6) Allelic Variant CYP2D6*10 In: Golden Helix Symposia 2015.
• PAN Y, TIONG KH, ABD-RASHID BA, ISMAIL Z, ISMAIL R, MAK JW, ONG CE, 2014. Effect of eurycomanone on cytochrome P450 isoforms CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2E1 and CYP3A4 in vitro Journal of Natural Medicines. 68(2), 402-6
• ONG CE, PAN Y, 2014. Drug-herb interactions: mechanisms involved and clinical implications of five commonly and traditionally used herbs TANG: HUMANITAS MEDICINE. 4(3), 17.1-17.8
• ONG CE and PAN Y, 2014. Drug-herb interactions: mechanisms involved and clinical implications of five commonly and traditionally used herbs Tang. 4(3), 17.1-17.8
• PAN Y, PAN Y, TIONG KH, ABD-RASHID BA, ISMAIL Z, ISMAIL R, MAK JW and ONG CE, 2014. In vitro effect of important herbal active constituents on human cytochrome P450 1A2 (CYP1A2) activity Phytomedicine. 21(12), 1645-1650
• TAN BH, PAN Y, PALANISAMY UD, OTHMAN I, YIAP BC and ONG CE, 2014. In vitro modulatory effects of glucosamine, chondroitin and diacerein on human hepatic cytochrome P450 2C9 activity In: 24th Singapore Pharmacy Congress.
• DONG AN, PAN Y, PALANISAMY UD, ISMAIL R and ONG CE, 2014. Functional characterization of cytochrome P450 2D6 (CYP2D6) allelic variants CYP2D6*2 and CYP2D6*17 In: Pharmacology & Physiology International Scientific Congress.
• PAN Y, MAK JW and ONG CE, 2013. Heterologous expression of human cytochrome P450 (CYP) 2C19 in Escherichia coli and establishment of RP-HPLC method to serve as activity marker. Biomedical chromatography : BMC. 27(7), 859-865
• ONG CE, PAN Y, MAK JW and ISMAIL R, 2013. In vitro approaches to investigate cytochrome P450 activities: update on current status and their applicability. Expert opinion on drug metabolism & toxicology.
• ONG CE, PAN Y, ABD-RASHID BA, ISMAIL Z, ISMAIL R and MAK JW, 2013. Studies of in vitro modulatory effect of Labisia pumila on CYP1A2, CYP2A6 and CYP3A4 In: 10th International ISSX Meeting.
• TAN BH, PAN Y, PALANISAMY UD, OTHMAN I, YIAP BC and ONG CE, 2013. Effects of glucosamine, chondroitin and diacerein on human hepatic cytochrome P450 3A4 activity in vitro In: 13th International Congress of Toxicology.
• DONG AN, TAN BH, SIONG WL, PAN Y, PALANISAMY UD and ONG CE, 2013. Site-directed mutagenesis of human cytochromes P450 (CYPs): generation of common mutants of CYP2D6 and CYP2C19 In: International Conference on Advances in Medical Science.
• PAN Y, TIONG KH, ABD-RASHID BA, ISMAIL Z, ISMAIL R, MAK JW and ONG CE, 2012. Inhibitory effects of cytochrome P450 enzymes CYP2C8, CYP2C9, CYP2C19 and CYP3A4 by Labisia pumila extracts. Journal of ethnopharmacology. 143(2), 586-91
• PAN, Y., MAK, J.W. and ONG, C. E., 2012. Development and Validation of HPLC Methods for the Determination of CYP2D6 and CYP3A4 Activities Current Pharmaceutical analysis. 8, 219-224
• PAN Y, ABD-RASHID BA, ISMAIL Z, ISMAIL R, MAK JW and ONG CE, 2012. In vitro effect of various herbal active constituents on cytochrome P450 2E1 In: Malaysia Pharmaceutical Society-Pharmacy Scientific Conference 2012.
• PAN Y, ABD-RASHID BA, ISMAIL Z, ISMAIL R, MAK JW and ONG CE, 2012. Evaluation of the modulatory effect of Labisia Pumila extracts on cytochrome P450 2C8 in vitro In: the 19th Microsomes and Drug Oxidations (MDO) and 12th European International Society for the Study of Xenobiotics (ISSX) Meeting.
• PAN Y, ABD-RASHID BA, ISMAIL Z, ISMAIL R, MAK JW, POOK PCK, ER HM and ONG CE, 2011. In vitro determination of the effect of Andrographis paniculata extracts and andrographolide on human hepatic cytochrome P450 activities. Journal of natural medicines. 65(3-4), 440-7
• PAN Y, ABD-RASHID BA, ISMAIL Z, ISMAIL R, MAK JW, POOK PCK, ER HM and ONG CE, 2011. In vitro effects of active constituents and extracts of Orthosiphon stamineus on the activities of three major human cDNA-expressed cytochrome P450 enzymes. Chemico-biological interactions. 190(1), 1-8
• PAN Y, ABD-RASHID BA, ISMAIL Z, ISMAIL R, MAK JW, POOK PCK, ER HM and ONG CE, 2011. In vitro modulatory effects of Andrographis paniculata, Centella asiatica and Orthosiphon stamineus on cytochrome P450 2C19 (CYP2C19). Journal of ethnopharmacology. 133(2), 881-7
• PAN, Y., ABD-RASHID, B.A., ISMAIL, Z., ISMAIL, R., MAK, J.W. and ONG, C. E., 2011. Heterologous expression of human cytochromes P450 2D6 and CYP3A4 in Escherichia coli and their functional characterization The Protein Journal. 30(2), 581-591
• PAN Y, ABD-RASHID BA, ISMAIL Z, ISMAIL R, MAK JW and ONG CE, 2011. Studies of in vitro modulatory effects of Labisia pumila on cytochrome P450 2C19 In: Malaysia Pharmaceutical Society-Pharmacy Scientific Conference 2011.
• PAN Y, ABD-RASHID BA, ISMAIL Z, ISMAIL R, MAK JW and ONG CE, 2011. In vitro modulatory effects of Labisia pumila on cytochrome P450 2C9 In: 25th Scientific Meeting of the Malaysian Society of Pharmacology and Physiology.
• PAN Y, ABD-RASHID BA, ISMAIL Z, ISMAIL R, MAK JW and ONG CE, 2011. Evaluation of in vitro effects of various herbal active constituents on cytochrome P450 In: 25th Scientific Meeting of the Malaysian Society of Pharmacology and Physiology.
• PAN Y, ABD-RASHID BA, ISMAIL Z, ISMAIL R, MAK JW, POOK PCK, ER HM and ONG CE, 2010. In vitro modulatory effects on three major human cytochrome P450 enzymes by multiple active constituents and extracts of Centella asiatica. Journal of ethnopharmacology. 130(2), 275-83
• PAN Y, ABD-RASHID BA, ISMAIL Z, ISMAIL R, MAK JW, POOK P, ER HM and ONG CE, 2009. Evaluation of the modulatory effect of Orthosiphon stamineus (Misai kucing) on the activity of expressed human CYP2C19 In: the 3rd Regional Conference on Molecular Medicine.
• SINGH, R., TING, J. G., PAN, Y., TEH, L. K., ISMAIL, R. and ONG, C. E., 2008. Functional role of Ile264 in CYP2C8: mutations affect haem incorporation and catalytic activity Drug Metab Pharmacokinet. 23(3), 165-74
• ONG, C. E., PAN, Y., TIONG, K.H., YIAP, B.C., TAN, E.L., POOK, P. and MAK, J.W., 2008. Pharmacogenomics in drug therapy and interaction: the role of cytochrome P450 International e-Journal of Science, Medicine & Education. 2(Suppl 1), S6-S10
• PAN Y, ABD-RASHID BA, ISMAIL Z, ISMAIL R, MAK JW, POOK P, ER HM and ONG CE, 2008. Effects of Centella asiatica extracts and active constituents on cytochrome P450 3A4 (CYP3A4) activity In: the Australian Health and Medical Research Congress.
• PAN Y, ABD-RASHID BA, ISMAIL Z, ISMAIL R, MAK JW, POOK P and ONG CE, 2008. Effects of Andrographis paniculata extracts on cytochrome P450 3A4 (CYP3A4) activity In: the 8th MPS Pharmacy Scientific Conference.
• PAN Y, ABD-RASHID BA, ISMAIL Z, ISMAIL R, MAK JW, POOK P and ONG CE, 2008. Effects of Andrographis paniculata extracts on cytochrome P450 2D6 (CYP2D6) acitivities In: MSPP 22nd Scientific Meeting, Faculty of Medicine.
• PAN Y, ABD-RASHID BA, ISMAIL Z, MINERS JO, BIRKETT DJ, ISMAIL R, MAK JW, POOK P and ONG CE, 2007. Effects of Hempedu bumi extracts and constituents on CYP2C9 in human liver In: the Commonwealth Pharmaceutical Association - MPS Pharmacy Scientific Conference.