Siu Yee New

Contact

• workRoom B1A05 B1-block
  Malaysia Campus
  Jalan Broga
  43500 Semenyih
  Selangor Darul Ehsan
  Malaysia
• work+6 (03) 8924 8762
• SiuYee.New@nottingham.edu.my

Biography

Dr New Siu Yee received her BSc from University of Technology Malaysia (UTM) and her PhD from National University of Singapore (NUS). During her PhD study, she was involved in multidisciplinary fields of study with three different research groups and spent a year attachment at University of Illinois at Urbana-Champaign (UIUC). After graduated, Dr New worked as Scientist I in Institute Materials Research and Engineering (IMRE), A*Star, Singapore, before joining the University of Nottingham Malaysia. Her current research interest focuses on nanotechnology based biosensors.

Personal research webpage:

https://newsy1019.wixsite.com/newgroup

Expertise Summary

• Crystallization techniques for both small molecules and proteins.
• Various characterization techniques: UV-vis, FTIR, 1D and 2D NMR, electron paramagnetic resonance (EPR), powder X-ray Diffraction (XRD), electrospray ionization-mass spectroscopy (ESI-MS), circular dichroism (CD), spectrofluorometer, surface plasmon resonance (SPR-Biacore), quartz crystal microbalance (QCM), dynamic light scattering (DLS), cyclic voltammetry (CV), thermal gravimetric analysis (TGA), etc.
• Experience in polymerase chain reaction (PCR), protein expression and purification (fast protein liquid chromatography-FPLC),
• Experience in handling Schlenk line, TLC, column chromatography, Soxhlet extraction and vacuum liquid chromatography (VLC).
• Experience in simple modeling using Visual Molecular Dynamic (VMD).

Teaching Summary

Dr. New teaches across the School of Pharmacy's degree programmes, contributing to the MPharm, BPharm and BSc in Pharmaceutical and Health Sciences. She serves as Programme Director for… read more

Research Summary

Principal Investigator/ Main Applicant (UNM)

2024 - 2025: Principal Investigator (PI); FOSE Interdisciplinary Research Fund, "Nanokit: Hands-on Nanoscience Learning for School Students Leading to Future Prototyping", RM 20,000

2024 - 2025: PI; UNM Student Experience Innovation Fund, "Fostering Student Wellbeing and Inclusion: A Cross-Campus EDI Awareness and Training Initiative", RM 26,250.

2024: Main applicant; RSC Researcher Collaboration Grant, "Biosensing with DNA Nanotechnology: From Design to Application", £2190

2023 - 2024: Main applicant; RSC Research Fund, "A Controllable Approach to Construct Hybridisation Chain Reaction-Silver Nanoclusters Hybrid Assay", £ 4,978

2021: Winner; L'Oreal UNESCO Fellowship for Women in Science - Young Talent Program Awards, "A Smart Way to Construct New Generation of DNA Biosensor", RM 30,000

2020 - 2021: Supervisor; MAKNA Cancer Research Award 2020, Colourimetric Nanosensor for the Detection of Ovarian Cancer Biomarker miRNA-665", RM 30,000

2019 - 2021: Facile and PCR-Free Detection of miRNA Using Magnetic Separation and Fluorescent Silver Nanoclusters (Fundamental Research Grant Scheme (FRGS), Ministry of Education (MOE))

2018: SERS Analysis on Reverse Aggregation Control of Cysteamine Coated Gold Nanoparticles (Royal Society of Chemistry; Mobility Grant)

2015 - 2017: Novel Colorimetric & Fluorogenic Nanobiosensors for Telomerase Activity Detection (FRGS, MOE)

2014 - 2015: Systematic Preparation of New Fluorogenic Silver Nanoclusters for Sensing Application (UNMC pump-priming project)

Collaborator

2027 - 2028: Collaborator; UNM Student Experience, "Students for Impact: Empowering Leadership, Sustainability and Community Engagement Beyond the Classroom", RM 7,000

2026 - 2027: Collaborator; Teaching & Learning Innovation Grant, "Enhancing Academic English Communication Through Embedded Structured Peer Interaction (ESPI) in Higher Education", RM 15,800

2024 - 2025: Collaborator; FOSE Interdisciplinary Research Fund, "Advancing Aptamer Technologies for Colorectal Cancer: From Enhanced Biomarker Detection to Cellular Therapeutic Interaction", RM 20,000

2021 - 2023: Synthesis of protein gold nanoclusters for delivery of silencing-RNA as synergistic colorectal cancer therapy and in situ bioimaging (FRGS, MOE)

2020 - 2021: Colourimetric Nanosensor for the Detection of Ovarian Cancer Biomarker miRNA-665 (MAKNA Cancer Research Award 2020)

2019 - 2020: Detection of Breast Cancer Biomarker miRNA-155 Using Hybridisation Chain Reaction and Silver Nanoclusters (Taylor's University Emerging Research Grant)

2017 - 2019: Elucidation graphene antimicrobial properties against intracellular Staphyloccoccus aureus from bovine mastitis (FRGS, MOE)

2016 - 2019: Development of Multimode "Turn-On" Protein-Gold Nanoclusters for Targeted Theranostics and Imaging of Colon Cancer and Its Metastases (FRGS, MOE)

Selected Publications

• NEW SIU YEE, CHEUNG EDWIN and SU XIAO DI, 2013. A Method to screen small ligands and determine protein-ligand interactions (Singapore Patent) 201303835-1 05/16/2013 00:00:00
• NEW SIU YEE, SU XIAO DI and TAN YEN NEE, 2013. Protein-Based Fluorescent Metal Nanoclusters for Drug Screening (Singapore Patent) 201306645-1 09/01/2013 00:00:00
• STEVEN LUKMAN, NEW SIU YEE, CHEUNG EDWIN and SU XIAO DI, 2013. A Hybrid Sensor using Metal Nanoparticles and Conjugated Polymers (Singapore Patent) 201303638-9 05/10/2013 00:00:00
• KE LIN, LIM WAI KWAN, NEW SIU YEE, SU XIAO DI and LIU BIN, 2013. Immunosensor Characterization Using Impedance Spectroscopy Journal of Biosensors & Bioelectronics. 4(4),

• View all publications

Dr. New teaches across the School of Pharmacy's degree programmes, contributing to the MPharm, BPharm and BSc in Pharmaceutical and Health Sciences. She serves as Programme Director for Pharmaceutical and Health Sciences and as Chemistry Lead for the BPharm programme. Her teaching covers medicinal chemistry and drug discovery, pharmaceutical and biological chemistry, pharmaceutical analysis and spectroscopy, and systems-based pharmaceutical science. Her wider academic responsibilities extend from Foundation to postgraduate level, including moderation at Foundation level and postgraduate research examination.

She adopts a research-led approach to teaching, integrating current developments in nanotechnology, biosensing and pharmaceutical sciences into student research projects, and supervises Final Year Project students and postgraduate researchers in these areas.

Past Research

Co-Principal Investigator (IMRE, Singapore)

2012 - 2013: Development of biogenic fluorescent metal nanoclusters for biosensing and clinical diagnosis (IMRE core funded project)

Scientist I (IMRE, Singapore)

2012 - 2013: Integrative analysis of the ongogenic transcription factors, AP-2γ and FoxA1 in breast cancer using nanobiotechnology and genome biology (A*Star JCO funded project)

2011 - 2012: Heterogeneous phase displacement immunoassays for urinary protein markers (Industrial project: IMRE - Nitto Denko Asia Technical Centre Pte. Ltd)

PhD (NUS, Singapore)

2007 - 2011: Supramolecular chemistry and crystal engineering of amino acid Schiff bases

2009 - 2010: Study the effect of site-directed mutagenesis on copper metalloprotein and protein crystallization (University of Illinois, Urbana-Champaign, USA)

Future Research

Please visit our group webpage:

https://newsy1019.wixsite.com/newgroup

• NEW, SIU YEE, YOONG CHAN, NATHANIEL JIA and YING OOI, JESSICA SUI, 2026. Employing a cluster transfer strategy in a hybridisation chain reaction–silver nanocluster hybrid sensor for nucleic acid detection Analytical Methods. 18(7), 1392-1396
• WONG, ZHENG WEI and NEW, SIU YEE, 2025. Recent Advances in Biosensors Based on Hybridization Chain Reaction and Silver Nanoclusters Small Methods. 9(4), 2401436
• OOI, JESSICAS. Y., RICHARDS, DANIEL A. and NEW, SIU YEE, 2025. ColorimetricBiosensor for Nucleic Acid DetectionUsing Hybridization Chain Reaction and Gold Nanoparticles: Effectof DNA Hairpin Sequence Modifications on Biosensor Performance Langmuir. 41(29), 19428-19436
• WONG, ZHENG WEI and NEW, SIU YEE, 2023. An enzyme-free turn-on fluorescent strategy for nucleic acid detection based on hybridization chain reaction and transferable silver nanoclusters MICROCHIMICA ACTA. 190(1),
• LIU, YIWEI, MARSHALL, NICHOLAS M., YU, SHENG-SONG, KIM, WANTAE, GAO, YI-GUI, ROBINSON, HOWARD, NILGES, MARK J., ZHANG, YAN, NEW, SIU YEE and LU, YI, 2023. StructuralBasis for the Effects of Phenylalanineon Tuning the Reduction Potential of Type 1 Copper in Azurin Inorganic Chemistry. 62(29), 11618-11625
• OOI, JESSICAS. Y., LIM, CHER RYN, HUA, CHAI XIAN, NG, JECK FEI and NEW, SIU YEE, 2023. DNA Hairpinsand Stabilization of Gold Nanoparticles:Effect of Stem Length and Toehold Composition Langmuir. 39(43), 15200-15207
• WU, YUTING, LEWIS, WHITNEY, WAI, JING LUEN, XIONG, MENGYI, ZHENG, JIAO, YANG, ZHENGLIN, GORDON, CHLOE, LU, YING, NEW, SIU YEE, ZHANG, XIAO-BING and LU, YI, 2023. Ratiometric Detection of Zn2+ Using DNAzyme-Based Bioluminescence Resonance Energy Transfer Sensors Chemistry. 5(3), 1745-1759
• OOI, JESSICA SUI YING and NEW, SIU YEE, 2022. Design Strategies of Gold Nanoparticles-Based Biosensors Coupled with Hybridization Chain Reaction or Catalytic Hairpin Assembly CHEMISTRYSELECT. 7(7),
• ZHENG WEI WONG, KASTURI MUTHOOSAMY, NUR ALIANA HIDAYAH MOHAMED and SIU YEE NEW, 2022. A ratiometric fluorescent biosensor based on magnetic-assisted hybridization chain reaction and DNA-templated silver nanoclusters for sensitive microRNA detection Biosensors and Bioelectronics: X. 12, 100244
• XIN YI WONG, DANIEL QUESADA-GONZÁLEZ, SIVAKUMAR MANICKAM, SIU YEE NEW, KASTURI MUTHOOSAMY and ARBEN MERKOÇI, 2021. Integrating gold nanoclusters, folic acid and reduced graphene oxide for nanosensing of glutathione based on “turn-off” fluorescence Scientific Reports. 11, 2375
• WONG, ZHENG WEI, NG, JECK FEI and NEW, SIU YEE, 2021. Ratiometric Detection of microRNA Using Hybridization Chain Reaction and Fluorogenic Silver Nanoclusters Chemistry – An Asian Journal. 16(24), 4081-4086
• WAI, JING LUEN and NEW, SIU YEE, 2020. Cysteamine-coated gold nanoparticles for bimodal colorimetric detection with inverse sensitivity: a proof-of-concept with lysozyme RSC ADVANCES. 10(2), 1088-1094
• SHI TING LEE, RUMAN RAHMAN, KASTURI MUTHOOSAMY, NUR ALIANA HIDAYAH MOHAMED, XIAODI SU and SAAD TAYYAB, 2019. Amplification-free and direct fluorometric determination of telomerase activity in cell lysates using chimeric DNA-templated silver nanoclusters Microchimica Acta. 186, 81
• LEE SHI TING, DAVID P BEAUMONT, KASTURI MUTHOOSAMY, SU XIAO DI and NEW SIU YEE, 2018. Formulation of DNA Chimera Templates: Effects on Emission Behavior of Silver Nanoclusters and Sensing Analytica Chimica Acta. 1010, 62-68 (IF = 4.95)
• JIAMIAO HU, SI KEE TAN, MICHELLE GEK LIANG LIM, SHIE HONG CHANG, GUIMEI CUI, SHANSHAN LIU, KAMESH NARASIMHAN, SIU YEE NEW, XUECONG WANG, CONGLING CHEN, HARAPRIYA CHAKRAVARTY, PRASANNA R KOLATKAR, KIN YIP TAM, QIAN LU, XIAODI SU, RALF JAUCH and EDWIN CHEUNG, 2018. Identification of a Wells–Dawson polyoxometalate-based AP-2γ inhibitor with pro-apoptotic activity Biochemical Journal. 475(11), 1965-1977
• LEE SHI TING and NEW SIU YEE, 2017. In-Depth Investigation on DNA-AgNCs Designs for Adenosine Detection In: Second International Conference on Molecular Diagnostics and Biomarker Discovery Conference, Penang, Malaysia.
• WAI JING LUEN and NEW SIU YEE, 2017. Gold Nanoparticles-based Colorimetric Aptasensor for Biomarker Detection In: Second International Conference on Molecular Diagnostics and Biomarker Discovery Conference, Penang, Malaysia.
• NEW SIU YEE and LEE SHI TING, 2017. Formulation of DNA Chimera Templates for Silver Nanoclusters (Invited) In: 25th PolyChar, PWTC, Kuala Lumpur, Malaysia..
• HOSSEINZADEH PARISA, MARSHALL NICHOLAS M., CHACÓN KELLY N., YU YANG, NILGES MARK J., NEW SIU YEE, TASHKOV STOYAN A., BLACKBURN NINIAN J. and LU YI, 2016. Design of a single protein that spans the entire 2-V range of physiological redox potentials Proceedings of the National Academy of Sciences of USA. (IF = ‎9.674)
• NEW SIU YEE*, LEE SHI TING and SU XIAO DI, 2016. DNA-templated silver nanoclusters: structural correlation and fluorescence modulation Nanoscale. 8, 17729–17746 (IF = 7.76)
• LEE SHI TING, DAVID BEAUMENT and NEW SIU YEE, 2016. In-Depth Investigation on DNA-AgNCs Designs for Adenosine Detection In: ICONAN, Paris, France.
• NEW SIU YEE and LEE SHI TING, 2016. Formulation of DNA-Templated Silver Nanoclusters: Location of Nucleation Sequence Matters In: Nano2016, Quebec, Canada.
• NEW SIU YEE, KHIN MOH MOH AUNG, YONG YU, XIE JIAN PING, LU YI, TAN YEN NEE, CHEUNG EDWIN and SU XIAO DI, 2015. Gold Nanosensors for Protein-Ligand Interactions In: IUPAC 2015, Busan, Korea.
• YU YONG, NEW SIU YEE, LIN JIAXIAN, SU XIAO DI and TAN YEN NEE, 2015. A Rapid and Quantitative Fluorimetric Method for Protein-Targeting Small Molecule Drug Screening Journal of Visualized Experiments. e53261 (IF = 1.325)
• KHIN MOH MOH AUNG, SIU YEE NEW, SHUZHEN HONG, LAURA SUTARLIE, MICHELLE GEK LIANG LIM, SI KEE TAN, EDWIN CHEUNG and XIAODI SU, 2014. Gold Nanoparticle Colorimetric Assay for Studying FoxA1-DNA Interactions and Ligand Inhibition: A Comparison with EMSA and Fluorescence Anisotropic Assay Analytical Biochemistry. 448, 95-104 (IF= 2.31)
• NEW, SIU YEE, AUNG, KHIN MOH MOH, LIM, GEK LIANG, HONG, SHUZHEN, TAN, SI KEE, LU, YI, CHEUNG, EDWIN and SU, XIAODI, 2014. Fast Screening of Ligand-Protein Interactions based on Ligand-Induced Protein Stabilization of Gold Nanoparticles Analytical Chemistry. 86(5), 2361-2370 (IF= 5.83)
• YU, YONG, NEW, SIU YEE (CONTRIBUTE EQUALLY), XIE, JIANPING, SU, XIAODI and TAN, YEN NEE, 2014. Protein-based fluorescent metal nanoclusters for small molecular drug screening Chemical Communications. (IF= 6.72)
• STEVEN LUKMAN, NEW SIU YEE and CHEUNG EDWIN, 2014. A Hybrid Sensor using Metal Nanoparticles and Conjugated Polymers (USA Patent) 14/275,526 05/12/2014 00:00:00
• NEW, SIU YEE, 2014. The ‘Revival’ of Nanosensors Austin Journal of Biosensors & Bioelectronics (Editorial). 1(1), 1
• NEW SIU YEE, CHEUNG EDWIN and SU XIAO DI, 2013. A Method to screen small ligands and determine protein-ligand interactions (Singapore Patent) 201303835-1 05/16/2013 00:00:00
• NEW SIU YEE, SU XIAO DI and TAN YEN NEE, 2013. Protein-Based Fluorescent Metal Nanoclusters for Drug Screening (Singapore Patent) 201306645-1 09/01/2013 00:00:00
• STEVEN LUKMAN, NEW SIU YEE, CHEUNG EDWIN and SU XIAO DI, 2013. A Hybrid Sensor using Metal Nanoparticles and Conjugated Polymers (Singapore Patent) 201303638-9 05/10/2013 00:00:00
• KE LIN, LIM WAI KWAN, NEW SIU YEE, SU XIAO DI and LIU BIN, 2013. Immunosensor Characterization Using Impedance Spectroscopy Journal of Biosensors & Bioelectronics. 4(4),
• NEW SIU YEE, SU XIAO DI and TAN YEN NEE, 2013. Bovine Serum Albumin Based Gold Nanocluster for Ligand Sensing In: SNIC-RSC Joint Symposium on Inorganic Chemistry, IMRE, Singapore.
• NEW, SIU YEE, MARSHALL, NICHOLAS M., HOR, T. S. ANDY, XUE, FENG and LU, YI, 2012. Redox tuning of two biological copper centers through non-covalent interactions: same trend but different magnitude CHEMICAL COMMUNICATIONS. 48(35), 4217-4219 (IF= 6.72)
• NEW SIU YEE, KHIN MOH MOH AUNG, TAN SI KEE, HONG SU ZHEN, CHEUNG EDWIN and SU XIAO DI, 2012. Gold Nanorods and Nanoparticles Derived Bioassays for Transcription Factors (AP-2γ and FoxA1)-DNA Binding Detection In: XI International Conference on Nanostructured Materials, Nano2012, Rhodes, Greece.
• NEW, SIU YEE, THIO, YUDE, KOH, LIP LIN, HOR, T. S. ANDY and XUE, FENG, 2011. Supramolecular assembly of a new series of copper-L-arginine Schiff bases CRYSTENGCOMM. 13(6), 2114-2122 (IF= 3.86)
• NEW, SIU YEE, WU, XUAN, BAI, SHI-QIANG, KOH, LIP LIN, HOR, T. S. ANDY and XUE, FENG, 2011. Lipid-bilayer-mimicking solid-state structures of Cu(II) and Ni(II) with L-tryptophan and L-tyrosine Schiff base derivatives CRYSTENGCOMM. 13(12), 4228-4235 (IF= 3.86)
• NEW SIU YEE, ANDY HOR TZI SUM and XUE FENG, 2008. Supramolecular Assembly Using Amino Acid Based Schiff Bases In: Inorganic Chemistry Conference (IC08), University of Canterbury Christchurch, New Zealand.
• NEW SIU YEE, ANDY HOR TZI SUM and XUE FENG, 2008. Supramolecular Assembly Using Amino Acid Based Schiff Bases In: Singapore-Hong Kong Bilateral Graduate Student Congress, NUS, Singapore.