Kuan Hon Lim

Contact

• workRoom B1A03 Block B
  Malaysia Campus
  Jalan Broga
  43500 Semenyih
  Selangor Darul Ehsan
  Malaysia
• work+6 (03) 8924 8208
• Kuanhon.Lim@nottingham.edu.my

Teaching Summary

Involved in the teaching of organic chemistry, analytical chemistry and medicinal chemistry to MPharm and Pharmaceutical and Health Sciences (BSc) students:

PHAR1008 - Pharmaceutical and Biological Chemistry

PHAR1011 - Dyspepsia

PHAR1022 - Laboratory Studies in Pharmaceutical Sciences 1

PHAR1025 - The Fundamentals of Pharmacy

PHAR2010 - Pharmaceutical Analysis and Spectroscopy (Module Leader)

PHAR2012 - Laboratory Studies in Pharmaceutical Sciences 2

PHAR2014 - Concepts in Medicinal Chemistry and Drug Discovery

PHAR2017 - Asthma, Allergies and Immune Diseases (Module Leader for UNM)

PHAR2021 - Pain

PHAR3014 - Medicinal Chemistry and Drug Design

Research Summary

Natural Products Chemistry

In our laboratory, we explore the flora of Malaysia for novel drug leads: isolation and structure determination of natural products possessing significant potential for application as therapeutic agents. We also pursue the total synthesis or semisynthesis of biologically active natural products. We carry out structural modification of natural products to understand the relationships between the molecular structure and its biological activity. We study natural products and novel structures for application in treatment of cancers, hypertension, and other disease-states. The major class of natural products that we are studying are alkaloids.

Selected Publications

• RAJA, V.J., LIM, K.H., LEONG, C.O., KAM, T.S. and BRADSHAW, T.D., 2014. Novel antitumour indole alkaloid, Jerantinine A, evokes potent G2/M cell cycle arrest targeting microtubules. Investigational new drugs. 32(5), 838-50
• KAM, TOH-SEOK and LIM, KUAN-HON, 2008. Alkaloids of Kopsia. In: CORDELL, G. A., ed., The Alkaloids: Chemistry and Biology 66. Academic Press: The Netherlands. 1-111
• LIM, K.H., ETOH, T., HAYASHI, M., LIM, K.H. and KAM, T.S., 2009. Conolutinine, a hexacyclic indole alkaloid with a novel ring system incorporating a diazaspiro center and fused oxadi-azepine-tetrahydrofuran rings Tetrahedron Letters. 50, 752-754
• LIM, K.H., HIRAKU, O., KOMIYAMA, K. and KAM, T.S., 2008. Jerantinines A-G, cytotoxic Aspidosperma alkaloids from Tabernaemontana corymbosa Journal of Natural Products. 71, 1591-1594

• View all publications

• KAYATRI GOVINDARAJU, YIN YING MAK, FONG KAI LEE, CLAUDIA C. BAUER, KUAN HON LIM, ROBIN S. BON, CIN KONG, SUE-MIAN THEN and KANG NEE TING, 2024. Vasorelaxant effect of a phenylethylamine analogue based on schwarzinicine A an alkaloid isolated from the leaves of Ficus schwarzii Phytochemistry Letters. 59, 24-35
• ABUZAID, HANEEN, ABDELRAZIG, SALAH, FERREIRA, LENNY, COLLINS, HILARY M., KIM, DONG-HYUN, LIM, KUAN-HON, KAM, TOH-SEOK, THOMAS, NEIL R., TURYANSKA, LYUDMILA and BRADSHAW, TRACEY D., 2024. Correction to “Apoferritin-Encapsulated Jerantinine A for Transferrin Receptor Targeting and Enhanced Selectivity in Breast Cancer Therapy” ACS Omega. 9(1), 2012-2012
• TAN Y.-S., NG M.-P., TAN C.H., TANG W.K., SIM K.S., YONG K.T., KRISHNAN P., LIM K.H., LIM S.H. and LOW Y.Y., 2024. Quinoline, Indole, and Isogranatanine Alkaloids from Malayan Leuconotis eugeniifolia Journal of Natural Products. 87, 286-296
• LIM K.H., MAI C.W., WONG S.K., LOW Y.Y., LIM S.H. and KRISHNAN P., 2024. Yunnanensine type indole and secostemmadenine-yunnanensine type bisindole alkaloids from the bark of Alstonia scholaris Phytochemistry Letters. 61, 97-103
• LI YIN PANG, SUE-MIAN THEN, KUAN HON LIM, KANG NEE TING and SHIN-YEE FUNG, 2023. Biopharmaceutical Potential of Ophiocordyceps sinensis for Human Health. In: DINESH CHANDRA AGRAWAL and MURALIKRISHNAN DHANASEKARAN, eds., Mushrooms with Therapeutic Potentials. Springer. 189–219
• TANG, S.-Y., TAN, C.-H., SIM, K.-S., YONG, K.-T., LIM, K.H., LOW, Y.-Y. and LIM, S.-H., 2023. Polyneurines A H, iboga alkaloids from Tabernaemontana polyneura Phytochemistry. 208, 113587
• TAN, Y.-S., WONG, S.-K., YONG, K.-T., LIM, K.H., LIM, S.-H. and LOW, Y.-Y., 2023. Eugeniifoline, a Pentacyclic Indole Alkaloid from Leuconotis eugeniifolia, and Configurational Revision of Synthetic Eugeniifoline Isolated from a Diversity-Enhanced Extract Journal of Natural Products. 86, 232–236
• TAN S.Y., NG M.-P., TAN C.H., SIM K.S., LIM K.H., YONG K.T., LOW Y.Y. and LIM S.H., 2023. Chippiine, iboga, cleavamine, vobasine, and cytotoxic bisindole alkaloids from Tabernaemontana polyneura Tetrahedron. 149, 133706
• CHU J.N., KRISHNAN P. and LIM K.H., 2023. A comprehensive review on the chemical constituents, sesquiterpenoid biosynthesis and biological activities of Sarcandra glabra Natural Products and Bioprospecting. 13, 53
• YIN-YING MAK, BI-JUIN LOONG, PAUL MILLNS, CLAUDIA C. BAUER, ROBIN S. BON, YVONNE MBAKI, FONG-KAI LEE, KUAN-HON LIM, CIN KONG and SUE-MIAN THEN, 2022. Schwarzinicine A inhibits transient receptor potential canonical channels and exhibits overt vasorelaxation effects Phytotherapy Research. 1-12
• PANG, LI-YIN, LEE, MEI-KEE, KONG, BOON HONG, FUNG, SHIN-YEE, NG, SZU TING, TAN, CHON SENG, THEN, SUE-MIAN, LIM, KUAN-HON, ROBERTS, RICHARD and TING, KANG-NEE, 2022. Chinese Caterpillar Mushroom, Ophiocordyceps sinensis (Ascomycota), Cold-Water Extract Relaxes the Rat Isolated Bladder INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS. 24(3), 1-14
• CHO, EUN-SEON, KRISHNAN, PREMANAND, LOH, HWEI-SAN, DALY, JANET M., LEONG, CHEE-ONN, MAI, CHUN-WAI, LOW, YUN-YEE, YONG, KIEN-THAI and LIM, KUAN-HON, 2022. Pentacyclic and hexacyclic cucurbitacins from Elaeocarpus petiolatus PHYTOCHEMISTRY. 193,
• ABUZAID, H., ABDELRAZIG, S., FERREIRA, L., COLLINS, H. M., KIM, D.-H., LIM, K. H., KAM, T.-S., TURYANSKA, L. and BRADSHAW, T. D., 2022. Apoferritin-Encapsulated Jerantinine A for Transferrin Receptor Targeting and Enhanced Selectivity in Breast Cancer Therapy ACS Omega.
• PAN YAN, UNG YEE TZE, PREMIKA A/P R JAGADISH, LIM KUAN HON, LAMIA NOUSHIN SADEQUE CHOWDHURY, SHANG TAO and ONG CHIN ENG, 2022. In Vitro Inhibitory Effects of Agarwood Tea (Aquilaria malaccensis Lamk) Aqueous Extract on Human Cytochrome P450 (CYP) Enzyme Activities Drug Metabolism Letter. 15, 178 - 191
• LEE, FONG-KAI, KRISHNAN, PREMANAND, MUHAMAD, AZIRA, LOW, YUN-YEE, KAM, TOH-SEOK, TING, KANG-NEE and LIM, KUAN-HON, 2021. Concise synthesis of the vasorelaxant alkaloids schwarzinicines A and B NATURAL PRODUCT RESEARCH.
• CHAN, ZI-YANG, KRISHNAN, PREMANAND, MODARESI, SAYED MOHAMMADHOSSEIN, HII, LING-WEI, MAI, CHUN-WAI, LIM, WEI-MENG, LEONG, CHEE-ONN, LOW, YUN-YEE, WONG, SOON-KIT, YONG, KIEN-THAI, LEONG, ALYSSA ZI-XIN, LEE, MEI-KEE, TING, KANG-NEE and LIM, KUAN-HON, 2021. Monomeric, Dimeric, and Trimeric Tropane Alkaloids from Pellacalyx saccardianus JOURNAL OF NATURAL PRODUCTS. 84(8), 2272-2281
• CHAN, ZI-YANG, KRISHNAN, PREMANAND, HII, LING -WEI, MAI, CHUN-WAI, LEONG, CHEE-ONN, LOW, YUN-YEE, WONG, SOON-KIT, TING, KANG-NEE, YONG, KIEN -THAI and LIM, KUAN-HON, 2021. Unusual diarylheptanoid-phenylpropanoid adducts and diarylheptanoid alkaloids from Pellacalyx saccardianus PHYTOCHEMISTRY LETTERS. 46, 36-44
• KRISHNAN, PREMANAND, LEE, FONG-KAI, YAP, VERONICA ALICIA, LOW, YUN-YEE, KAM, TOH-SEOK, YONG, KIEN-THAI, TING, KANG-NEE and LIM, KUAN-HON, 2020. Schwarzinicines A-G, 1,4-Diarylbutanoid-Phenethylamine Conjugates from the Leaves of Ficus schwarzii. Journal of natural products. 83(1), 152-158
• YAP, JING Y, HII, CHING L, ONG, SZE P, LIM, KUAN H, ABAS, FARIDAH and PIN, KAR Y, 2020. Effects of drying on total polyphenols content and antioxidant properties of Carica papaya leaves Journal of the Science of Food and Agriculture. 100(7), 2932-2937
• YEAP, JOANNE SOON-YEE, TAN, CHUN-HOE, YONG, KIEN-THAI, LIM, KUAN-HON, LIM, SIEW-HUAH, LOW, YUN-YEE and KAM, TOH-SEOK, 2020. Macroline, talpinine, and sarpagine alkaloids from Alstonia penangiana. An NMR-based method for differentiating between A. penangiana and A. macrophylla PHYTOCHEMISTRY. 176,
• ALHUTHALI, HAYAA MOEED, BRADSHAW, TRACEY D., LIM, KUAN-HON, KAM, TOH-SEOK and SEEDHOUSE, CLAIRE H., 2020. The natural alkaloid Jerantinine B has activity in acute myeloid leukemia cells through a mechanism involving c-Jun BMC CANCER. 20(1),
• PANG, L.Y., TAN, C.S., NG, S.T., LIM, K.H., THEN, S.M. and TING, K.N., 2020. Ophiocordyceps sinensis: a prominent source of bioactive components for alleviating overactive bladder Life Sciences, Medicine and Biomedicine. 4(9), 67
• ZI-YANG CHAN, KAYATRIGOVINDARAJU, PREMANAND KRISHNAN, YUN-YEE LOW, KAM-WENG CHONG, KIEN-THAI YONG, KANG-NEE TING and KUAN-HON LIM, 2019. Diphenethylpiperidine alkaloids with tracheal smooth muscle relaxation activity from Hippobroma longiflora (L.) G. Don Phytochemsitry Letters. 30, 93-98
• YEAP, JOANNE SOON-YEE, LIM, KUAN-HON, YONG, KIEN-THAI, LIM, SIEW-HUAH, KAM, TOH-SEOK and LOW, YUN-YEE, 2019. Lycopodium Alkaloids: Lycoplatyrine A, an Unusual Lycodine-Piperidine Adduct from Lycopodium platyrhizoma and the Absolute Configurations of Lycoplanine D and Lycogladine H JOURNAL OF NATURAL PRODUCTS. 82(2), 324-329
• KRISHNAN, PREMANAND, MAI, CHUN-WAI, YONG, KIEN-THAI, LOW, YUN-YEE and LIM, KUAN-HON, 2019. Alstobrogaline, an unusual pentacyclic monoterpenoid indole alkaloid with aldimine and aldimine-N-oxide moieties from Alstonia scholaris TETRAHEDRON LETTERS. 60(11), 789-791
• EZEOKE, M.C., KRISHNAN, P., SIM, D.S.Y., LIM, S.H., LOW, Y.Y., CHONG, K.W. and LIM, K.H., 2018. Unusual phenethylamine-containing alkaloids from Elaeocarpus tectorius Phytochemistry. 146, 75-81
• MEI-KEE LEE, KUAN-HON LIM, PAUL MILLNS, SURESH KUMAR MOHANKUMAR, SZU-TING NG, CHON-SENG TAN, SUE-MIAN THEN and YVONNE MBAKI, 2018. Bronchodilator effects of Lignosus rhinocerotis extract on rat isolated airways is linked to the blockage of calcium entry Phytomedicine. 42, 172-179
• MEI-KEE LEE, PAUL MILLNS, YVONNE MBAKI, SZU-TING NG, CHON-SENG TAN, KUAN-HON LIM, SUE-MIAN THEN, SURESH KUMAR MOHANKUMAR and KANG-NEE TING, 2018. Data on the Lignosus rhinocerotis water solublesclerotial extract affecting intracellular calciumlevel in rat dorsal root ganglion cells Data in Brief 18. 1322-1326
• ABUBAKAR, I.B, LIM, K.-H. and T.-S. KAM, 2018. Jerantinine B enhances the mitochondria-mediated apoptosis by p53 activation in human glioblastoma cells via a combination with δ-tocotrienol. Journal of Biologically Active Products from Nature. 8(1), 21-27
• SMEDLEY, CHRISTOPHER J., STANLEY, PAUL A., QAZZAZ, MOHANNAD E., PROTA, ANDREA E., OLIERIC, NATACHA, COLLINS, HILARY, EASTMAN, HARRY, BARROW, ANDREW S., LIM, KUAN-HON, KAM, TOH-SEOK, SMITH, BRIAN J., DUIVENVOORDEN, HENDRIKA M., PARKER, BELINDA S., BRADSHAW, TRACEY D., STEINMETZ, MICHEL O. and MOSES, JOHN E., 2018. Sustainable Syntheses of (-)-Jerantinines A & E and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site SCIENTIFIC REPORTS. 8,
• PREMANAND KRISHNAN, FONG-KAI LEE, KAM-WENG CHONG, CHUN-WAI MAI, AZIRA MUHAMAD, SIEW-HUAH LIM, YUN-YEE LOW, KANG-NEE TING and KUAN-HON LIM, 2018. Alstoscholactine and Alstolaxepine, Monoterpenoid Indole Alkaloids with γ‑Lactone-Bridged Cycloheptane and Oxepane Moieties from Alstonia scholaris Organic Letters. 20, 8014-8018
• SOO, HSIEN-CHUEN, CHUNG, FELICIA FEI-LEI, LIM, KUAN-HON, YAP, VERONICA ALICIA, BRADSHAW, TRACEY D., HII, LING-WEI, TAN, SI-HOEY, SEE, SZE-JIA, TAN, YUEN-FEN, LEONG, CHEE-ONN and MAI, CHUN-WAI, 2017. Cudraflavone C Induces Tumor-Specific Apoptosis in Colorectal Cancer Cells through Inhibition of the Phosphoinositide 3-Kinase (PI3K)-AKT Pathway PLOS ONE. 12(1),
• CHUNG FF, TAN PF, RAJA VJ, TAN BS, LIM KH, KAM TS, HII LW, TAN SH, SEE SJ, TAN YF, WONG LZ, YAM WK, MAI CW, BRADSHAW TD and LEONG CO, 2017. Jerantinine A induces tumor-specific cell death through modulation of splicing factor 3b subunit 1 (SF3B1). Scientific reports. 7, 42504
• ABUBAKAR, IBRAHIM BABANGIDA, LIM, KUAN-HON, KAM, TOH-SEOK and LOH, HWEI-SAN, 2017. Enhancement of apoptotic activities on brain cancer cells via the combination of gamma-tocotrienol and jerantinine A PHYTOMEDICINE. 30, 74-84
• AL-KHDHAIRAWI, AMJAD AYAD QATRAN, KRISHNAN, PREMANAND, MAI, CHUN-WAI, CHUNG, FELICIA FEI-LEI, LEONG, CHEE-ONN, YONG, KIEN-THAI, CHONG, KAM-WENG, LOW, YUN-YEE, KAM, TOH-SEOK and LIM, KUAN-HON, 2017. A Bis-benzopyrroloisoquinoline Alkaloid Incorporating a Cyclobutane Core and a Chlorophenanthroindolizidine Alkaloid with Cytotoxic Activity from Ficus fistulosa var. tengerensis JOURNAL OF NATURAL PRODUCTS. 80(10), 2734-2740
• QAZZAZ, M.E., RAJA, V.J., LIM, K.H., KAM, T.S., LEE, J.B., GERSHKOVICH, P. and BRADSHAW, T.D., 2016. In vitro anticancer properties and biological evaluation of novel natural alkaloid jerantinine B. Cancer Letters. 370, 185-197
• YAP, V.A., QAZZAZ, M.E., RAJA, V.J., BRADSHAW, T.D., LOH, H.-S., SIM, K.-S., YONG, K.-T., LOW, Y.-Y. and LIM, K.-H., 2016. Fistulopsines A and B antiproliferative septicine-type alkaloids from Ficus fistulosa. Phytochemistry Letters. 15, 136-141
• ABUBAKAR, I.B., LIM, K.-H., KAM, T.-S. and LOH, H.-S., 2016. Synergistic cytotoxic effects of combined δ-tocotrienol and jerantinine B on human brain and colon cancers. Journal of Ethnopharmacology. 184, 107–118
• WONG, S.P., CHONG, K.W., LIM, K.H., LIM, S.H., LOW, Y.Y. and KAM, T.S., 2016. Arborisidine and Arbornamine, Two Monoterpenoid Indole Alkaloids with New Polycyclic Carbon-Nitrogen Skeletons Derived from a Common Pericine Precursor ORGANIC LETTERS. 18, 1618-1621
• LEE, M.K., TAN, C.S., NG, S.T., LIM, K.H. and TING, K.N., 2016. Lignosus rhinocerotis on Airway Muscle Relaxation In: 19th ISMS Congress, at Amsterdam, The Netherlands.
• ABUBAKAR, I.B., LIM, K.-H. and LOH, H.-S., 2015. Alkaloid extracts of Ficus species and palm oil-derived tocotrienols synergistically inhibit proliferation of human cancer cells. Natural Product Research. 29(22), 2137-2140
• YAP, V.A., LOONG, B.-J., TING, K.N., LOH, H.-S., YONG, K.-T., LOW, Y.-Y., KAM, T.-S. and LIM, K.-H., 2015. Hispidacine, an unusual 8,4′-oxyneolignan-alkaloid with vasorelaxant activity, and hispiloscine, an antiproliferative phenanthroindolizidine alkaloid, from Ficus hispida Linn. Phytochemistry. 109, 96-102
• SANTIAGO, C., LIM, K.-H., LOH, H.-S. and TING, K.N., 2015. Inhibitory effect of Duabanga grandiflora on MRSA biofilm formation via prevention of cell-surface attachment and PBP2a production. Molecules. 20(3), 4473-4482
• SANTIAGO, C., LIM, K.-H., LOH, H.-S. and TING, K.N., 2015. Prevention of cell-surface attachment and reduction of penicillin-binding protein 2a (PBP2a) level in methicillin-resistant Staphylococcus aureus biofilms by Acalypha wilkesiana. BMC Complementary and Alternative Medicine. 15, 79
• LIM, K.H., RAJA, V.J., BRADSHAW, T.D., LIM, S.H., LOW, Y.Y. and KAM, T.S., 2015. Ibogan, Tacaman, and Cytotoxic Bisindole Alkaloids from Tabernaemontana. Cononusine, an Iboga Alkaloid with Unusual Incorporation of a Pyrrolidone Moiety Journal of Natural Products. 78(5), 1129-1138
• SANTIAGO, C., PANG, E.L., LIM, K.-H., LOH, H.-S. and TING, K.N., 2015. Inhibition of penicillin-binding protein 2a (PBP2a) in methicillin resistant Staphylococcus aureus (MRSA) by combination of ampicillin and a bioactive fraction from Duabanga grandiflora. BMC Complementary and Alternative Medicine. 15, 178
• SUET-PICK WONG, CHEW-YAN GAN, KUAN-HON LIM, KANG-NEE TING, YUN-YEE LOW and TOH-SEOK KAM, 2015. Arboridinine, a Pentacyclic Indole Alkaloid with a New Cage Carbon–Nitrogen Skeleton Derived from a Pericine Precursor Organic Letters. 17(14), 3628-3631
• LOONG, B.J., TAN, J.H., LIM, K.H., MBAKI, Y. and TING, K.N., 2015. Contractile function of smooth muscle retained after overnight storage Naunyn-Schmiedeberg's Archives of Pharmacology. 388(10), 1061-1067
• LIM, S.H., GAN, C.Y., LOW, Y.Y., LIM, K.H. and KAM, T.S., 2015. Lumutinines A-D, Linearly-fused Macroline-Macroline and Macroline-Sarpagine Bisindoles from Alstonia macrophylla In: 5th International Conference for Young Chemists, at Penang, Malaysia.
• SANTIAGO, C., PANG, E.L., LIM, K.H., LOH, H.S. and TING, K.N., 2014. Reversal of ampicillin resistance in MRSA via inhibition of penicillin-binding protein 2a by Acalypha wilkesiana. BioMed Research International. 965348
• LOW, Y.Y., HONG, F.J., LIM, K.H., THOMAS, N.F. and KAM, T.S., 2014. Transformations of the 2,7-Seco Aspidosperma alkaloid leuconolam, structure revision of epi-leuconolam, and partial syntheses of leuconoxine and leuconodines A and F. Journal of Natural Products. 77(2), 327-338
• RAJA, V.J., LIM, K.H., LEONG, C.O., KAM, T.S. and BRADSHAW, T.D., 2014. Novel antitumour indole alkaloid, Jerantinine A, evokes potent G2/M cell cycle arrest targeting microtubules. Investigational new drugs. 32(5), 838-50
• NGE CE, GAN CY, LIM KH, TING KN, LOW YY and KAM TS, 2014. Criofolinine and Vernavosine, New Pentacyclic Indole Alkaloids Incorporating Pyrroloazepine and Pyridopyrimidine Moieties Derived from a Common Yohimbine Precursor. Organic Letters. 16(24), 6330-3
• TAN, S.J., LIM, K.H., SUBRAMANIAM, G. and KAM, T.S., 2013. Macroline-sarpagine and macroline-pleiocarpamine bisindole alkaloids from Alstonia angustifolia Phytochemistry. 85, 194-202
• LIM, K.H., KOMIYAMA, K., KAM, T.S., LIM, K.H., THOMAS, N.F. and KAM, T.S., 2012. Perhentidines A-C: Macroline-macroline bisindoles from Alstonia and the absolute configuration of perhentinine and macralstonine Journal of Natural Products. 75, 945-950
• WIJAYA, S., TING, K.N., KHOO, T.J., LIM, K.H., LOH, H.S. and WIART, C., 2011. Antibacterial and antioxidant activities of Synedrella nodiflora (L.) Gaertn. (Asteraceae). Journal of Complementary and Integrative Medicine. 8(1), 13
• OTHMAN, M., LOH, H.S., WIART, C., KHOO, T.J., LIM, K.H. and TING, K.N., 2011. Optimal methods for evaluating antimicrobial activities from plant extracts. Journal of Microbiological Methods. 84(2), 161-166
• LIM, S.W., TING, K.N., BRADSHAW, T., ZEENATHUL, N.A., WIART, C., KHOO, T.J., LIM, K.H. and LOH, H.S., 2011. Acalypha wilkesiana extracts induce apoptosis by causing single strand and double strand DNA breaks Journal of Ethnopharmacology. 138, 616-623
• LOW, Y.Y., LIM, K.H., CHOO, Y.M., PANG, H.S., ETOH, T., HAYASHI, M., KOMIYAMA, K. and KAM, T.S., 2010. Structure, biological activity, and biomimetic partial synthesis of the lirofolines, novel pentacyclic indole alkaloids from Tabernaemontana Tetrahedron Letters. 51, 269-272
• LIM, K.H., THOMAS, N.F., THOMAS, N.F. and KAM, T.S., 2009. Seco-tabersonine alkaloids from Tabernaemontana corymbosa Phytochemistry. 70, 424-429
• LIM, K.H., SIM, K.M. and KAM, T.S., 2009. Four tetracyclic oxindole alkaloids and a taberpsychine derivative from a Malayan Tabernaemontana Phytochemistry. 70, 1182-1186
• LIM, K.H. and KAM, T.S., 2009. Conoliferine and isoconoliferine, unprecedented alkaloid-lignan conjugates from Tabernaemontana corymbosa Tetrahedron Letters. 50, 3756-3759
• LIM, K.H. and KAM, T.S., 2009. Conomicidines A and B, unusual alkaloid-hydroxycinnamyl alcohol conjugates from Tabernaemontana corymbosa Helvetica Chimica Acta. 92, 1895-1902
• LIM, K.H., ETOH, T., HAYASHI, M., LIM, K.H. and KAM, T.S., 2009. Conolutinine, a hexacyclic indole alkaloid with a novel ring system incorporating a diazaspiro center and fused oxadi-azepine-tetrahydrofuran rings Tetrahedron Letters. 50, 752-754
• LOW, Y.Y., SUBRAMANIAM, G., LIM, K.H., WONG, R.C.S., ROBINSON, W.T. and KAM, T.S., 2009. Mersiphyllines A and B from Kopsia. Determination of relative configuration at a quaternary center via formation of an alkaloid-borane complex Tetrahedron. 65, 6873-6876
• LIM, K.H., LOW, Y.Y., TAN, G.H., KAM, T.S. and LIM, T.M., 2008. Kopsine and danuphylline alkaloids from Kopsia. Biomimetic partial synthesis of danuphylline B. Helvetica Chimica Acta. 91, 1559-1566
• LIM, KUAN-HON and KAM, TOH-SEOK, 2008. Some novel biologically active alkaloids from Tabernaemontana and Kopsia In: International Conference on Molecular Chemistry, November 2008, Kuala Lumpur.
• LIM, K.H., HIRAKU, O., KOMIYAMA, K. and KAM, T.S., 2008. Jerantinines A-G, cytotoxic Aspidosperma alkaloids from Tabernaemontana corymbosa Journal of Natural Products. 71, 1591-1594
• LIM, K.H. and KAM, T.S., 2008. Methyl chanofruticosinate alkaloids from Kopsia arborea. Phytochemistry. 69, 558-561
• KAM, TOH-SEOK and LIM, KUAN-HON, 2008. Alkaloids of Kopsia. In: CORDELL, G. A., ed., The Alkaloids: Chemistry and Biology 66. Academic Press: The Netherlands. 1-111
• LIM, K.H., HIRAKU, O., KOMIYAMA, K., KOYANO, T., HAYASHI, M. and KAM, T.S., 2007. Biologically active indole alkaloids from Kopsia arborea Journal of Natural Products. 70, 1302-1307
• LOW, YUN-YEE, LIM, KUAN-HON and KAM, TOH-SEOK, 2007. Biomimetic oxidative transformations of pericine: Partial synthesis of apparicine and valparicine, a new pentacyclic indole alkaloid from Kopsia In: 12th Asian Chemical Congress, August 2007, Kuala Lumpur.
• LIM, K.H. and KAM, T.S., 2007. Secoleuconoxine and oxopericine derivatives from Kopsia. Helvetica Chimica Acta. 90, 31-35
• LIM, K.H., KOMIYAMA, K. and KAM, T.S., 2007. Arboricine and arboricinine, unusual tetracyclic indole regioisomers from Kopsia. Tetrahedron Letters. 48, 1143-1145
• LIM, K.H., LOW, Y.Y. and KAM, T.S., 2006. Biomimetic oxidative transformations of pericine: partial synthesis of apparicine and valparicine, a new pentacyclic indole alkaloid from Kopsia Tetrahedron Letters. 47, 5037-5039
• LIM, K.H. and KAM, T.S., 2006. Arboflorine, an unusual pentacyclic monoterpenoid indole alkaloid incorporating a third nitrogen atom Organic Letters. 8, 1733-1735
• LIM, KUAN-HON and KAM, TOH-SEOK, 2006. Structure, biological activity, and partial synthesis of some novel Kopsia alkaloids In: 22nd Annual Seminar of the Malaysian Natural Product Society and 5th Asian Network of Research on Antidiabetic Plants International Seminar (Oral Presentation), November 2006, Kuala Lumpur.
• LIM, K.H. and KAM, T.S., 2006. Arbophylline, a novel heptacyclic indole with a cage skeleton incorporating an acetal moiety Tetrahedron Letters. 47, 8653-8655
• KAM, T.S., SUBRAMANIAM, G., LIM, K.H. and CHOO, Y.M., 2004. Mersicarpine, an unusual tetracyclic dihydroindole alkaloid incorporating a seven-membered imine ring Tetrahedron Letters. 45, 5995-5998
• KAM, T.S., LIM, K.H., YOGANATHAN, K., HAYASHI, M. and KOMIYAMA, K., 2004. Lundurines A-D, cytotoxic indole alkaloids incorporating a cyclopropyl moiety from Kopsia tenuis and revision of the structures of tenuisines A-C Tetrahedron. 60, 10739-10745