Yuh-Fen Pung

Contact

• workRoom B1B20 Block B1
  Malaysia Campus
  Jalan Broga
  43500 Semenyih
  Selangor Darul Ehsan
  Malaysia
• work+6 (03) 8725 3748
• fax+6 (03) 8924 8018
• YuhFen.Pung@nottingham.edu.my

Biography

I obtained my Ph.D degree in Biological Sciences from the National University of Singapore. After graduation I did my post-doctoral trainings in Singapore, United States and United Kingdom prior to joining Division of Biomedical Sciences at the University of Nottingham Malaysia as Assistant Professor. My research interests have been trying to understand the role(s) of mitochondrial function and oxidative stress in cardiovascular pathophysiology. I am well-trained in biochemical techniques and specialized surgical procedures in rodents. I welcome research collaborations related to obesity, diabetes, hypertension and vascular biology. Besides, I am interested to understand the biological functions of metal oxide nanoparticles.

Teaching Summary

I am currently involved in teaching the following modules;-

Year 1

BIOM1001 Scientific Basis of Medicine

Year 2

LIFE2087 Structure, Function and Analysis of Proteins

LIFE2088 Pharmacological Basis of Therapeutics

LIFE2090 Signaling and Metabolic Regulation

Year 3

LIFE3054 Biochemistry of Diseases

LIFE3089 Biomedical Science Final Year Project

I am the module convenor for the following modules:-

LIFE2090 Signalling and Metabolic Regulation

LIFE3054 Biochemistry of Diseases

Research Summary

Current research focus on using mitochondrial bioenergetics to address issues related to obesity, diabetes, hypertension and cardiovascular physiopathology. Besides, I am using mitochondrial function… read more

Recent Publications

• LOW HC, CHILIAN WM, RATNAM W, KARUPAIAH T, MD NOH MF, MANSOR F, NG ZX and PUNG YF, 2023. Changes in Mitochondrial Epigenome in Type 2 Diabetes Mellitus. Brit J Biomed Sci. 80, 10884. doi:10.3389/bjbs.2023.10884
• TEY KW, WEN WX, BEE PC, ENG HS, HO KW, TAN SM, ANUAR NA and PUNG YF, 2023. KIR genotype and haplotype frequencies in a multi-ethnic population of Malaysia. Human Immunol. 84(3), 172-185 (IF: 2.211)
• PAN Y, JAGADISH PR, UNG YT, LIM SYM, LIM KH, LOO JSE, PUNG YF and CHOWDHURY LNS, 2023. Modulatory effects of Mangiferin isolated from Aquilaria plants on human Cytochrome P450 enzyme (CYP) activities in vitro and in silico studies. J Nat Prod. 13(8), e070323214440 (IF: 4.803)
• KIYOOKA T, OHANYAN V, YIN L, PUNG YF, CHEN YR, CHEN CL, KANG PT, HARDWICK JP, YUN J, JANOTA D, PENG J, KOLZ CL, GUARINI G, WILSON G, SHOKOLENKO I, STEVENS DA and CHILIAN WM, 2022. Mitochondrial DNA integrity and function are critical for endothelium-dependent vasodilation. Basic Res Cardiol. 117(1), 3 (IF: 17.165)

• View all publications

Current Research

Current research focus on using mitochondrial bioenergetics to address issues related to obesity, diabetes, hypertension and cardiovascular physiopathology. Besides, I am using mitochondrial function as the surrogate to assess toxicity of nanomaterials in eukaryotic cells and microbes.

• LOW HC, CHILIAN WM, RATNAM W, KARUPAIAH T, MD NOH MF, MANSOR F, NG ZX and PUNG YF, 2023. Changes in Mitochondrial Epigenome in Type 2 Diabetes Mellitus. Brit J Biomed Sci. 80, 10884. doi:10.3389/bjbs.2023.10884
• TEY KW, WEN WX, BEE PC, ENG HS, HO KW, TAN SM, ANUAR NA and PUNG YF, 2023. KIR genotype and haplotype frequencies in a multi-ethnic population of Malaysia. Human Immunol. 84(3), 172-185 (IF: 2.211)
• PAN Y, JAGADISH PR, UNG YT, LIM SYM, LIM KH, LOO JSE, PUNG YF and CHOWDHURY LNS, 2023. Modulatory effects of Mangiferin isolated from Aquilaria plants on human Cytochrome P450 enzyme (CYP) activities in vitro and in silico studies. J Nat Prod. 13(8), e070323214440 (IF: 4.803)
• KIYOOKA T, OHANYAN V, YIN L, PUNG YF, CHEN YR, CHEN CL, KANG PT, HARDWICK JP, YUN J, JANOTA D, PENG J, KOLZ CL, GUARINI G, WILSON G, SHOKOLENKO I, STEVENS DA and CHILIAN WM, 2022. Mitochondrial DNA integrity and function are critical for endothelium-dependent vasodilation. Basic Res Cardiol. 117(1), 3 (IF: 17.165)
• LEONG AZX, LEE PY, MOHTAR M, SYAFRUDDIN SE, PUNG YF and LOW TY, 2022. Short Open Reading Frames (sORFs) and microproteins: An update on their identification and validation measures. J Biomed Sci. 29, 19-34 (IF: 8.41)
• NG TW, TAN PPS, LIM HM, KUMAR DN, MOHD ZAIN S, LOW TY and PUNG YF, 2022. Potential medicinal herbs for cardiovascular health: A comprehensive review on Salviae miltiorrhizae. Mal Appl Biol J. 51(1), 1-20 (IF: 0.6)
• KARRISA P, SIMPSON T, DAWSON S, LOW TY, TAY SH, AMIN NORDIN FD, MOHD ZAIN S, LEE PY and PUNG YF, 2022. Comparison between Dichloroacetate and Phenylbutyrate treatment for pyruvate dehydrogenase deficiency. Brit J Biomed Sci. 79, 10382 (IF: 3.829)
• ZAIN SM, PUNG YF and MOHAMED R, 2022. Association of vaspin rs2236242 with type 2 diabetes mellitus and obesity: A meta-analysis of case-control studies. J Diabetes Metab Disord (IF:1.421 ).
• TING CY, TAN SY, GAN GG, ZAIN SM, PUNG YF, ONG DBL and BEE PC, 2022. Downregulation of hsa-miR-548d-3p and overexpression of HOXA9 in diffuse large B-cell lymphoma patients and the risk of R-CHOP chemotherapy resistance and disease progression. Int J of Lab Hematol. 44(5), 907-917 (IF: 2.877)
• JAMALPOUR S, ZAIN SM, VAZIFEHMAND R, MOHAMED Z, PUNG YF and KAMYAB H, 2022. Analysis of serum sirculating microRNAs level in Malaysian patients with gestational diabetes mellitus. Sci Rep. 12, 20295 (IF: 4.996)
• TAN PPS, SANDHU RS, ZAIN SM, HALL D, TAN NC, LIM HM and DAUD F, 2022. Health motivations and perceived barriers are determinants of self-care behaviour for the prevention of hypertension in a Malaysian community. PLoS One. 17(12), e0278761 (IF: 3.752)
• ESA E, HASHIM AK, MOHAMED EHM, ZAKARIA Z, ABU HASSAN AN, YUSOFF YM, KAMALUDDIN NR, RAHMAN AZA, CHANG KM, MOHAMED R, SUBBIAH I, JAMIAN E, HO CSL, LIM SM, LAU PC, PUNG YF and MOHD ZAIN S, 2021. Construction of a microRNA-mRNA Regulatory Network in De Novo Cytogenetically Normal Acute Myeloid Leukemia Patients Genet Test Mol Biomarkers. 25(3), 199-210 (IF: 1.210)
• CHONG CL, FANG CM, PUNG SY, ONG CE, PUNG YF, KONG C and PAN Y, 2021. Current Updates On the In vivo Assessment of Zinc Oxide Nanoparticles Toxicity Using Animal Models Bionanosci. (IF: 0.277)
• TING YW, KONG ASY, MOHD ZAIN S, CHAN WK, TAN HL, MOHAMED Z, PUNG YF and MOHAMED R, 2021. Loss-of-function HSD17B13 variants, non-alcoholic steatohepatitis and adverse liver outcomes: results from a multi-ethnic Asian cohort. Clin Mol Hepatol. 27, 486-498 (IF: 6.074)
• TAN PPS, HALL D, CHILIAN WM, CHIA YC, MOHD ZAIN S, LIM HM, KUMAR DN, CHING SM, LOW TY, MD NOH MF and PUNG YF, 2021. Exosomal microRNAs in the development of essential hypertension and its potential as biomarkers. J Physiol Heart Circ Physiol. 320(4), H1486-H1497 (IF: 4.012)
• RUNCHAROEN C, FUKUNAGA K, SENSORN I, IEMWIMANGSA N, KLUMSATHIAN S, TONG H, VO NS, LE L, HLAING TM, THANT M, MOHD ZAIN S, MOHAMED Z, PUNG YF, CAPULE F, NEVADO J, SILAO CL, AL-MAHAYRI ZN, AL BR, YULIWULANDARI R, PRAYUNI K, ZAHROH H, NOOR DAM, XANGSAYARATH P, XAYAVONG D, KOUNNAVONG S, SAYASONE S, KORDOU Z, LIOPETAS I, TSIKRIKA A, TSERMPINI EE, KOROMINA M, MITROPOULOU C, PATRINOS GP, KESORNSIT A, CHAROENYINGWATTANA A, WATTANAPOKAYAKIT S, MAHASIRIMONGKOL S, MUSHIRODA T and CHANTRATITA W, 2021. Prevalence of pharmacogenomic variants in 100 pharmacogenes among Southeast Asian populations under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm) Hum Genome Var. 8(1), 1-6 (IF: 1.312)
• NGUYEN D, CHILIAN WM, MOHD ZAIN S, DAUD MF and PUNG YF, 2021. Micro-RNA Regulation of Vascular Smooth Muscle Cells and Its Significance in Cardiovascular Diseases. Can. J. Physiol Pharmacol. (IF: 1.946)
• LOW TY, SYAFRUDDIN SE, MOHTAR MA, VELLAICHAMY A, RAHMAN NSA, PUNG YF and TAN CSH, 2021. Recent progress in mass spectrometry-based strategies for elucidating protein-protein interactions CELLULAR AND MOLECULAR LIFE SCIENCES. 78(13), 5325-5339 (IF: 6.496)
• LEE PY, YEOH Y, OMAR N, PUNG YF, LIM LC and LOW TY, 2021. Molecular tissue profiling by MALDI imaging: recent progress and applications in cancer research CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES. (IF: 4.677)
• NGUYEN D, MOHD ZAIN S, KAMARULZAMAN MH, LOW TY, CHILIAN WM, PAN Y, TING KN, HAMID A, ABDUL KADIR A and PUNG YF, 2021. Intracellular and exosomal miRNAome profiling of human vascular smooth muscle cells during replicative senescence. J Physiol Heart Circ Physiol.. 321(4), H770-783 (IF: 4.012)
• HO JS, AZIZ AI, PUNG YF, CHEW HY, PUNG SY, YING YL and PUNG SY, 2020. Potent antifungal activity of ZnO Nanoparticles on R. mucilaginosa is mediated by reactive oxygen species and zinc ion. IOSR-JEN. 10(4), 44-57
• SOH FCO, KEE JH, THIEN MY, YING YL, LE CF, NGUYEN D, GOH BH, PUNG SY and PUNG YF, 2018. Antibacterial activity by ZnO nanorods and ZnO nanodisks: A model used to illustrate "Nanotoxicity Threshold". J Ind Eng Chem. 62, 333-340 (IF: 4.421)
• THEIN MY, PUNG SY, CHUAH LS and PUNG YF, 2018. Photodegradation behavior of ZnO nanorods on various types of organic dyes. Advances in Materials and Processing Technologies. 4(2), 272-280
• YING YL, PUNG SY, ONG MT and PUNG YF, 2018. Rhodomine B dye removal and inhibitory effect on B. subtilis and S. aureus by WOx nanoparticles. J Ind Eng Chem. 67, 437-447 (IF: 4.421)
• THEIN MY, CHIRM JE, PUNG SY and PUNG YF, 2017. Highly UV light driven WOx@ZnO nanocomposites synthesized by liquid impregnation method. J Ind Eng Chem. 46, 119-29 (IF: 4.421)
• PUNG YF, CHILIAN WM, BENNETT MR, FIGG N and KAMARULZAMAN MH, 2017. The JCR:LA-cp rat: a novel rodent model of cystic medial necrosis. American journal of physiology. Heart and circulatory physiology. 312(3), H541-H545 (IF: 4.012)
• PUNG YF, KMETZ J, BRATZ I, MURPHY MP and SMITH RAJ, 2017. MitoQuinone rescues aortic endothelial function mediated through eNOS/NO pathway. FASEB J. 31(1), S1080.14 (IF: 5.480)
• YING YL, PUNG SY, ONG MT and PUNG YF, 2017. A comparison study between ZnO nanorods and WO3/ZnO nanorods in Bromocresol green dye removal. Solid State Phenomena. 264, 87-90 (IF: 0.39)
• YU EPK, REINHOLD J, YU H, STARKS L, URYGA A, FOOTE K, FINIGAN A, FIGG N, PUNG YF, LOGAN A, MURPHY MP and BENNETT MR, 2017. Mitochondrial respiration is reduced in atherosclerosis, promoting necrotic core formation and reducing relative fibrous cap thickness Arterioscler Thromb Vasc Biol. 37(12), 2322-2332 (IF: 5.533)
• GUARINI G, KIYOOKA T, OHANYAN V, PUNG YF, MARZILLI M, CHEN YR, CHEN CL, KANG PT, HARDWICK JP, KOLZ CL, YIN L, WILSON GL, SHOKOLENKO I, DOBSON JG, FENTON R and CHILIAN WM, 2016. Impaired coronary metabolic dilation in the metabolic syndrome is linked to mitochondrial dysfunction and mitochondrial DNA damage. Basic research in cardiology. 111(3), 29-42 (IF: 5.414)
• PUNG YF, SAM WJ, HARDWICK JP, YIN L, OHANYAN V, LOGAN S, DI VINCENZO L and CHILIAN WM, 2013. The role of mitochondrial bioenergetics and reactive oxygen species in coronary collateral growth. American journal of physiology. Heart and circulatory physiology. 305(9), H1275-80 (IF: 4.012)
• PUNG YF, SAM WJ, STEVANOV K, ENRICK M, CHEN C, KOLZ C, THAKKER P, HARDWICK JP, CHEN Y, DYCK JRB, YIN L and CHILIAN WM, 2013. Mitochondrial oxidative stress corrupts coronary collateral growth by activating adenosine monophosphate activated kinase-α signaling. Arteriosclerosis, thrombosis, and vascular biology. 33(8), 1911-9 (IF: 5.533)
• CHILIAN WM, PENN MS, PUNG YF, DONG F, MAYORGA M, OHANYAN V, LOGAN S and YIN L, 2012. Coronary collateral growth--back to the future. Journal of molecular and cellular cardiology. 52(4), 905-11 (IF: 5.218)
• PUNG YF, ROCIC P, MURPHY MP, SMITH RAJ, HAFEMEISTER J, OHANYAN V, GUARINI G, YIN L and CHILIAN WM, 2012. Resolution of mitochondrial oxidative stress rescues coronary collateral growth in Zucker obese fatty rats. Arteriosclerosis, thrombosis, and vascular biology. 32(2), 325-34 (IF: 5.533)
• YIN L, OHANYAN V, PUNG YF, DELUCIA A, BAILEY E, ENRICK M, STEVANOV K, KOLZ CL, GUARINI G and CHILIAN WM, 2012. Induction of vascular progenitor cells from endothelial cells stimulates coronary collateral growth. Circulation research. 110(2), 241-52 (IF: 11.089)
• PUNG YF and CHILIAN WM, 2010. Corruption of coronary collateral growth in metabolic syndrome: Role of oxidative stress. World journal of cardiology. 2(12), 421-7
• CARRÃO ACR, CHILIAN WM, YUN J, KOLZ C, ROCIC P, LEHMANN K, VAN DEN WIJNGAARD JPHM, VAN HORSSEN P, SPAAN JAE, OHANYAN V, PUNG YF and BUSCHMANN I, 2009. Stimulation of coronary collateral growth by granulocyte stimulating factor: role of reactive oxygen species. Arteriosclerosis, thrombosis, and vascular biology. 29(11), 1817-22 (IF: 5.533)
• GAO L, PUNG Y, ZHANG J, CHEN P, WANG T, LI M, MEZA M, TORO L and CAI H, 2009. Sepiapterin reductase regulation of endothelial tetrahydrobiopterin and nitric oxide bioavailability. American journal of physiology. Heart and circulatory physiology. 297(1), H331-9 (IF: 4.012)
• YUN J, ROCIC P, PUNG YF, BELMADANI S, CARRAO ACR, OHANYAN V and CHILIAN WM, 2009. Redox-dependent mechanisms in coronary collateral growth: the "redox window" hypothesis. Antioxidants & redox signaling. 11(8), 1961-74 (IF: 7.667)
• BELMADANI S, MATROUGUI K, KOLZ C, PUNG YF, PALEN D, PROCKOP DJ and CHILIAN WM, 2009. Amplification of coronary arteriogenic capacity of multipotent stromal cells by epidermal growth factor. Arteriosclerosis, thrombosis, and vascular biology. 29(6), 802-8 (IF: 5.533)
• CHILIAN WM and PUNG YF, 2008. Vascular endothelial growth factor and the collateral circulation: the story continues. Circulation research. 103(9), 905-6 (IF: 11.089)
• RAJAGOPALAN N, PUNG YF, ZHU YZ, WONG PTH, KUMAR PP and KINI RM, 2007. Beta-cardiotoxin: a new three-finger toxin from Ophiophagus hannah (king cobra) venom with beta-blocker activity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 21(13), 3685-95 (IF: 5.480)
• WONG JJY, PUNG YF, SZE NS and CHIN K, 2006. HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets. Proceedings of the National Academy of Sciences of the United States of America. 103(28), 10735-40 (IF: 9.809)
• PUNG YF, KUMAR SV, RAJAGOPALAN N, FRY BG, KUMAR PP and KINI RM, 2006. Ohanin, a novel protein from king cobra venom: its cDNA and genomic organization. Gene. 371(2), 246-56 (IF: 2.082)
• PUNG YF, WONG PTH, KUMAR PP, HODGSON WC and KINI RM, 2005. Ohanin, a novel protein from king cobra venom, induces hypolocomotion and hyperalgesia in mice. The Journal of biological chemistry. 280(13), 13137-47 (IF: 4.600)