Involved in the teaching of organic chemistry, analytical chemistry and medicinal chemistry to MPharm and Pharmaceutical and Health Sciences (BSc) students:
BP1M01 - The Science of Medicine Manufacture
B31B07 - Pharmaceutical and Biological Chemistry
B31DYS - Dyspepsia
B32AAI - Asthma, Allergies and Immune Diseases (Module Leader for UNMC)
B32C05 - Pharmaceutical Analysis and Spectroscopy (Module Leader)
B32C08 - Laboratory Studies in Pharmaceutical Sciences and Pharmacology
B32C09 - Concepts in Medicinal Chemistry and Drug Discovery (Module Leader)
B33E06 - Medicinal Chemistry and Drug Design
Natural product chemistry and Organic synthesis for structure activity relationship studies
My major research interests focus on discovery of novel natural products from plants, particularly alkaloids and triterpenoids, which possess interesting biological activities. The common activities involved in my research include extraction of plant material, chromatographic isolation of compounds, NMR structure elucidation, chemical modification of natural products, and biological evaluation of pure compounds and derivatives. The various analytical/separation tools employed in my research include NMR, high resolution MS, FT-IR, UV-vis, single crystal X-ray crystallography, circular dichroism, and various chromatographic techniques.
The various plant natural products obtained will be biological evaluated regarding their potential as anticancer, vasorelaxation, and anticholinesterase agents. In cases where potential therapeutic agents were discovered, synthesis and/or semi-synthesis will be carried out to study structure-activity relationships with the aim to uncover analogues with improved biological activity.
RAJA, V.J., LIM, K.H., LEONG, C.O., KAM, T.S. and BRADSHAW, T.D., 2014. Novel antitumour indole alkaloid, Jerantinine A, evokes potent G2/M cell cycle arrest targeting microtubules. Investigational new drugs. 32(5), 838-50 KAM, TOH-SEOK and LIM, KUAN-HON, 2008. Alkaloids of Kopsia. In: CORDELL, G. A., ed., The Alkaloids: Chemistry and Biology 66. Academic Press: The Netherlands. 1-111 LIM, K.H., ETOH, T., HAYASHI, M., LIM, K.H. and KAM, T.S., 2009. Conolutinine, a hexacyclic indole alkaloid with a novel ring system incorporating a diazaspiro center and fused oxadi-azepine-tetrahydrofuran rings Tetrahedron Letters. 50, 752-754
LIM, K.H., HIRAKU, O., KOMIYAMA, K. and KAM, T.S., 2008. Jerantinines A-G, cytotoxic Aspidosperma alkaloids from Tabernaemontana corymbosa Journal of Natural Products. 71, 1591-1594