University of Nottingham Malaysia
Faculty of Science
     
  
 

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Sue-Mian Then

Associate Professor,

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Biography

Dr Sue-Mian Then obtained both of her bachelor's and PhD's degrees from Universiti Kebangsaan Malaysia (UKM). She worked as a research fellow at the UKM Medical Molecular Biology Institute (UMBI) from 2007-2012 and joined the University of Nottingham Malaysia (UNM) in July 2012 and has been working until present. She is now an Associate Professor of the university since 2015. She also obtained her Post Graduation Certificate in Higher Education (PGCHE) in July 2016. She is currently the lead for animal ethics for the campus, she is involved in the local review and facilitates researchers from the campus to obtain their animal ethics approval from Animal Welfare and Ethics Review Board (AWERB), UK.

Her research interest is in elucidating mechanism of action of natural compounds, neuroscience, pharmacogenetics and Science, Technology, Engineering and Mathematics (STEM) education. Her research grants includes investigation of gamma-tocotrienol (gT3), a vitamin E isomer from palm oil as a potential anti-cancer treatment for neuroblastoma; development of mobile genetic detector to detect genes (HLA-B*15:02 and HLA-B*58:01) to prevent severe drug-induced adverse reaction.

Teaching Summary

Module Convener for:

BIOM1001 Scientific Basis of Medicine (Autumn)

LIFE1052 Human Physiology

LIFE2089 Neurobiology of Diseases

I also contribute lectures to other modules such as LIFE1051 Fundamentals of Neuroscience, LIFE2088 Pharmacological Basis of Therapeutics, BIOM3003 Cancer Biology, LIFE3050 Molecular Pharmacology, LIFE3052 Concepts of Pharmacogenetics. As personal tutor, I guide my tutee with their BIOM1002 Core Skills in Biomedical Sciences assignments.

I'm interested in utilising collaborative learning and peer learning to help improved students' understanding and appreciation of histology for the Autumn semester component HDT Human Development and Tissue Differentiation in the BIOM1001 Scientific Basis of Medicine by designing a cross-campus collaborative revision activity near the end of semester to aid in the students' revision. The outcome of this approach has been positive with our students demonstrated marked academic improvement.This work has been presented in HEA seminar and the manuscript is in progress.

Research Summary

Area of research

Research Interest

1. Basic Neuroscience: Oxidative stress and tocotrienol signaling in neurons

2. Neurodegenerative diseases: safety and efficacy of neural stem cell transplantation as therapeutics for Alzheimer's disease

3. Pharmacogenomics: Development of a rapid protocol for detection of HLA-B*1502 allele in epileptic patients to prevent carbamazepine-induced Steven-Johnson syndrome (SJS)

4. Gravitational and Space Biology of Eukaryotic Cells and C elegans

Citation index

Total Citation

1. Web of Knowledge: Total citation=100, H-index=4

2. Scopus: Total citation = 137, H-index=5

3. Google Scholar: Total citation=158, H-index=5

Research projects

Title of Research Projects

1. Development of a portable screening kit to detect HLA-B*1502 and HLA-B*5801 to prevent Carbamazepine, Phenytoin, Oxocarzepine and Allopurinol induced-Steven Johnson Syndrome (Principle Investigator), MOSTI eScience, RM300,000.00. 2014-2016

2. Establishing pre-clinical evidence of gamma-tocotrienol as potential anti-tumor therapeutic agent against neuroblastoma by targeting the BH3 domain of the Bcl-2 family proteins involved in apoptosis signaling pathway in an animal model (Principle Investigator), MOHE FRGS, RM147,040.00. 2014-2017

3. RNA Interference-Mediated Silencing Effects of Genes Involved in Longevity, DNA Repair and Locomotion of Caenorhabditis Elegans Exposed to Microgravity and Orbital Forces (Co-researcher), Geran Pembangunan Sains Angkasa dan Mikrogravity, ANGKASA, MOSTI, RM 520,000.00. 2012-2015

4. Interrogating the role of gamma-tocotrienol as potential anti-tumor therapeutic agent through the apoptosis signalling pathway in human neuroblastoma cell line by in silico molecular target and molecular functional study (Principal Investigator), FRGS MOHE, RM 135,750.00 2012-2013

5. Development and validation of an in-house fast screening protocol and kit for HLA-B*1502 and Cw*0801 polymorphism to prevent Carbamazepine induced- Steven Johnson Syndrome (SJS) (Principal Investigator), Malaysia Neuroscience Society Grant, RM20,000.00 2011-2013

6. Elucidating the possible mechanism of action of gamma-Tocotrienol's Cellular Transport and Signalling pathway Modulate by Gamma-Tocotrienol (Principal Investigator), Geran Galakan Penyelidik Muda UKM (UKM-GGPM-TKP-072-2010), RM 50,000.00 2010-2012

7. Gene Silencing Effects of Bcl-2, Bax, p53, p 38, ERK and PKC in Oxidative Stress-Induced Neurons: Potential Modulatory Role of Palm Oil Y-Tocotrienol in neuronal apoptosis (Principal Investigator), FRGS MOHE, RM78,000.00 2010-2012

8. A System Biology Approach to Study Alzheimer's disease: Neural Stem Cell Diffrenentiation, Pathophysiology in An Alzheimner's disease (AD) Mouse Model and response to neural stem cell transplantation (Co-researcher & Project Manager), Geran Arus Perdana UKM (UKM-AP-TKP-08-2009), RM690,000.00 2009-2011

Recent Publications

Faculty of Science

University of Nottingham Malaysia
Jalan Broga, 43500 Semenyih
Selangor Darul Ehsan
Malaysia

telephone: +6 (03) 8924 8000
fax: +6 (03) 8924 8018

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